生殖医学杂志2017，Vol.26Issue(2)：143-147,5.DOI:10.3969/j.issn.1004-3845.2017.02.008
地屈孕酮在促排卵周期宫腔内人工授精黄体支持中的应用
Application of dydrogesteron to luteal support in hyperstimulation cycle for artificial insemination
王美仙 1张扬 1谈海英 1沈骜 1王磊 1邵小光1
作者信息
- 1. 大连市妇女儿童医疗中心,大连市生殖与遗传医学中心,大连 116000
- 折叠
摘要
Abstract
Objective:To explore the effect of dydrogesterone for luteal support in the hyperstimulation cycle onthe outcome of artificial insemination.Methods:A total of 617 patients(1 594 cycles) underwent to our center for intrauterine insemination from 2013 to 2014.Three hundred and sixty seven patients completed 367 natural cycles for monitoring ovulation before IUI cycle as the natural cycle group.Twenty eight hyperstimulation cycles without luteal support were canceled IUI as canceled IUI without luteal support group.According to the luteal support method after IUI,the patients were divided into two groups:the patients were given dydrogesterone in group A(1 076 cycles),and the patients were administrated progesterone capsules in group B(518 cycles).The luteal phase days and the incidence of corpus luteum insufficiency were compared among the groups.The rates of pregnancy,abortion,ectopic pregnancy,live birth and the incidence of fetal abnormalities were compared between group A and group B.Results:The luteal phase days were not significantly different between groups A and group B [(13.80± 0.80) vs.(13.83±0.90) days],but which were significantly higher than those in the group without luteal support [(12.00± 1.12) days] (P＜0.05).The incidence of corpus luteum insufficiency in group A and group B [0.86％ and 0.78％,respectively] was significantly lower than that in the natural cycle group (4.36 ％) and the group without luteal support(32.14 ％)(P＜0.05).There were no differences in rates of pregnancy,miscarriage,ectopic pregnancy,live birth,neonatal birth weight,Apgar score,and fetal abnormalities between the group A and B(P＞0.05).Conclusions:Application of dydrogesterone for luteal support is effective and safe in the hyperstimulation cycle of artificial insemination.关键词
地屈孕酮/促排卵/宫腔内人工授精/黄体支持Key words
Dydrogesterone/Hyperstimulation/Artificial insemination/Luteal support引用本文复制引用
王美仙,张扬,谈海英,沈骜,王磊,邵小光..地屈孕酮在促排卵周期宫腔内人工授精黄体支持中的应用[J].生殖医学杂志,2017,26(2):143-147,5.
