天津中医药2017，Vol.34Issue(3)：186-189,4.DOI:10.11656/j.issn.1672-1519.2017.03.12
佩兰对2型糖尿病合并脂代谢紊乱大鼠肝脏肌醇必需酶1α表达的影响
Influence of the inositol-requiring enzyme 1a(IRE1α) in the liver getted mice with type 2 diabetes mellitus and hyperlipidemia after treatment by the fortune's eupatoium herb
摘要
Abstract
[Objective] To reserch the influence of inositol-requiring enzyme 1α (IRE1α) in liver getted mice with type 2 diabetes mellitus and hyperlipidemia after treatment by fortune's eupatorium herb. [Methods] The successful builted mice were randomly assigned into four groups, model group feed by 2 mL/d saline, peilan treatment group feed by fortune's eupatorium herb 3 g/(kg·d) and pioglitazone treatment group feed by pioglitazone in 0.3 mg/(kg·d), and 10 normal mice were sized to be a group. Mice were treated for 5 weeks, and the blood glucose, triglyceride, cholestenone and insulin were invested, then the eXpression of the IRE1α's mRNA and protein were invested.[Results] Compared with the model group,the triglyceride and cholestenone in fortune's eupatorium herb treatment group turned to be better, and the impression of mRNA and protein in liver was lower. [Conclusion] Fortune's eupatorium herb can improve the content of IRE1αin the organs of mice with type 2 diabetes mellitus and hyperlipidemia.关键词
2型糖尿病/脂代谢紊乱/佩兰/IRE1αKey words
fortune's eupatorium herb/nositol-requiring enzyme 1α/type 2 diabetes mellitus/hyperlipidemia分类
医药卫生引用本文复制引用
薛超,何百川,韩一益,章清华,吴深涛..佩兰对2型糖尿病合并脂代谢紊乱大鼠肝脏肌醇必需酶1α表达的影响[J].天津中医药,2017,34(3):186-189,4.基金项目
国家自然科学基金资助项目(81273710). （81273710）
