天津中医药2017，Vol.34Issue(3)：204-207,4.DOI:10.11656/j.issn.1672-1519.2017.03.16
木香在胃肠安丸中药效作用靶点与颗粒剂等效性评价
Study on radix aucklandiae pharmacodynamic targets in Weichang'an pill and the equivalent evaluation of formula particles
摘要
Abstract
[Objective] This experiment selected radix aucklandiae as principal drug of Weichang'an pills. By analyzing principal com-ponent and pharmacological effects, it was probed pharmacodynamic material basis of Weichang'an pills and contrast radix aucklandiae formula particles and decoction pharmacodynamic differences, evaluate the equivalence objectively. [Methods] This experiment adopt infrared spectrometry (IR) and high performance liquid chromatography (HPLC) to analyze all the components and principal component content of radiX aucklandiae. By gastric emptying and intestinal propellant movement, hot plate reaction and rotating body reaction prob-ing the mechanism of regulation and equivalent evaluation of formula particles. [Results] Radix aucklandiae can reduce the of rategastric remnant, improve the rate of propeling carbon powder in small intestin. There was no significant difference between radix aucklandiae de-coction and formula particles. [Conclusion] Radix aucklandiae can relieve pain by promoting gastrointestinal peristalsis and adjusting the gastrointestinal dynamia. Although formula particles and decoction have some differences in kinds and contents, but the effect is similar.关键词
木香/配方颗粒/胃肠推进/镇痛/等效性评价Key words
radix aucklandiae/formula particles/intestinal propellant movement/analgesia/equivalent evaluation分类
医药卫生引用本文复制引用
张强,马露,尹云泽,唐方..木香在胃肠安丸中药效作用靶点与颗粒剂等效性评价[J].天津中医药,2017,34(3):204-207,4.基金项目
天津市科委科技创新专项基金资助(06FZ-ZDSH00405). （06FZ-ZDSH00405）
