现代妇产科进展2017，Vol.26Issue(3)：183-185,190,4.DOI:10.13283/j.cnki.xdfckjz.2017.03.005
拟行辅助生殖技术夫妇染色体核型分析
The chromosome karyotype analysis for assisted reproductive technology couples
卫玉玲 1史云芳 2李晓洲 2宋学茹 2琚端 2张颖2
作者信息
- 1. 天津医科大学,天津 300070
- 2. 天津医科大学总医院,天津 300052
- 折叠
摘要
Abstract
Objective:To analyze the abnormality of chromosome karyotype in the cou-ples undergoing IVF or ICSI and discuss the necessity of chromosome karyotype analysis. To provide guidance for genetic counseling and the option of assisted reproductive method. Meth-od:2621 patients undergoing IVF or ICSI in General Hospital of Tianjin Medical University in recent fifteen years were taken as study object,including 1365 males and 1256 females,using the method of G-banding karyotype analysis of the peripheral blood. Taking the abnormality rate and polymorphism rate in general population as control. Results:71 cases of chromosome abnor-mality were found with the abnormal rate of 2 . 71%, 35 cases of abnormality were found in males with the abnormal rate of 2 . 56%. 36 cases in females and the abnormal rate was 2 . 87%. Chromosome polymorphism rate was 4. 85%,which was more higher than the rate of gen-eral population. The chromosome abnormal rate of the spontaneous abortion group had no differ-ent with the rate of general population. Conclusion:The chromosome abnormality rate in the as-sisted reproductive patients is higher than the general population. It is necessary to take chromo-some karyotype analysis before IVF or ICSI.关键词
染色体异常/多态性/生殖异常/体外受精/单精子胞浆内注射-胚胎移植Key words
Chromosome aberration/Chromosome polymorphism/Reproductive abnor-malities/In vitro fertilization/intracytoplasmic sperm injection-embryo transfer分类
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卫玉玲,史云芳,李晓洲,宋学茹,琚端,张颖..拟行辅助生殖技术夫妇染色体核型分析[J].现代妇产科进展,2017,26(3):183-185,190,4.
