现代妇产科进展2017，Vol.26Issue(3)：194-198,5.DOI:10.13283/j.cnki.xdfckjz.2017.03.007
欣普贝生用于足月胎膜早破低宫颈评分引产的效果观察
Vaginal prostaglandin E2 for labor induction in premature rupture of membranes at term with low Bishop score
刘海燕 1叶旭萍 2杨燕 1张铮 1顾蔚蓉 1李笑天1
作者信息
- 1. 复旦大学附属妇产科医院,上海 200011
- 2. 上海市女性生殖内分泌相关疾病重点实验室,上海 200011
- 折叠
摘要
Abstract
Objective:The aim of this study was to compare the efficacy and safety of a prostaglandin E2 ( PGE2 ) vaginal insert with those of oxytocin for labor induction in premature rupture of membranes ( PROM) at term with low Bishop score in nulliparous women. The pres-ent study also examined whether its use increase the rate of vaginal delivery in them. Methods:A total of 100 PROM women with singleton pregnancies at term,Bishop scores of≤4 were as-signed to receive either oxytocin or vaginal PGE2 in the context of informed consent. There are 50 cases in the vaginal PGE2 group and the oxytocin group,respectively. The primary outcomes were time from induction to vaginal delivery and mode of delivery. Results:Compared with the oxytocin group,the total effective rate of cervical ripening was obviously increased in the PGE2 group after 8 and 12 hours ( 92 . 0% vs 64 . 5%, P<0 . 01;95 . 9% vs 79 . 2%, P<0 . 05 ) . The vaginal delivery within 12 and 24 hours were significant raised in the PGE2 group (42. 0% vs 8. 0%,P<0. 001;64. 0% vs 34. 0%,P<0. 01) and the total vaginal delivery rate was in-creased (86. 0% vs 60. 0%,P<0. 01). The time from labor induction to active labor onset and vaginal delivery were significantly shorter in the PGE2 group than those in the oxytocin group (7. 4±1. 0 vs 14. 2±2. 0h,P<0. 01;15. 4±1. 4 vs 21. 4±1. 6h,P<0. 01). The incidence of in-duction failure and chorioamnionitis were declined in the PGE2 group (2. 0% vs 16. 0%,P<0 . 05;0 vs 12 . 0%, P<0 . 05 ) . There were no statistically significant difference in the rates of precipitate labor,fetal distress and relative cephalopelvic disproportion of the two groups. Neo-natal outcomes were comparable in both groups. Conclusion:It was safe and efficient to use va-ginal administration of PGE2 treatment for cervical ripening and induction of term pregnancy with PROM in nulliparous women,and its efficacy was superior to oxytocin,however,monitoring should be intensified.关键词
欣普贝生/胎膜早破/宫颈Bishop评分/引产/催产素Key words
Prostaglandin E2/Pemature rupture of membranes/Bishop score/Labor induction/Oxytocin分类
医药卫生引用本文复制引用
刘海燕,叶旭萍,杨燕,张铮,顾蔚蓉,李笑天..欣普贝生用于足月胎膜早破低宫颈评分引产的效果观察[J].现代妇产科进展,2017,26(3):194-198,5.
