现代妇产科进展2017，Vol.26Issue(3)：199-202,206,5.DOI:10.13283/j.cnki.xdfckjz.2017.03.008
高龄孕妇对2种不同唐氏产前诊断方案的需求及经济学评价
The demand and economic evaluation of two strategies for Down syndrome prenatal diagnosis in pregnant women with advanced maternal age
摘要
Abstract
Objective:To explore the demand of two options for Down syndrome prena-tal diagnosis in pregnant women with advanced maternal age,we did perform economic evalua-tion of two options. Methods:From March 12015 to March 312016,a total of 4104 singleton pregnant women of advanced maternal age who required outpatient before 20+6 weeks of gesta-tion at Shenzhen Maternity and Child Healthcare Hospital were recruited for this study. Women were asked to choose between strategy 1 ( NIPT as the initial screening,amniocentesis if positive result from NIPT) and strategy 2 ( universal amniocentesis) . The demand and influencing fac-tors of two strategies were compared,and economic evaluation of two strategies were also per-formed. Results:The percentage of women choosing strategy 1 was higher than that of women choosing strategy 2[51. 34%(2107/4104)vs 7. 65%(314/4104),X2=1883. 431,P<0. 001], and Logistic regression analysis showed that maternal age, the result of traditional Down syn-drome screening and nuchal translucency ( NT) were influencing factors. Strategy 1 could save 67 . 21% costs compared with strategy 2 . Conclusion:There is great demand for NIPT in preg-nant women of advanced maternal age. Moreover,amniocentesis for the women with positive re-sult from NIPT can save medical costs. After detail counseling,pregnant women of advanced ma-ternal age can be offered NIPT as the initial screening,especially in women with younger age, non-high risk for traditional Down syndrome screening and normal NT.关键词
唐氏综合征/产前诊断/需求/经济学评价Key words
Down syndrome/Prenatal diagnosis/Demand/Economic evaluation分类
医药卫生引用本文复制引用
涂新枝,段纯,袁晖,李玉哲,谢建生..高龄孕妇对2种不同唐氏产前诊断方案的需求及经济学评价[J].现代妇产科进展,2017,26(3):199-202,206,5.基金项目
广东省医学科研基金(No:B2015059) （No:B2015059）
深圳市科技研发资金知识创新计划基础研究项目(No:JCYJ20150402090412996) （No:JCYJ20150402090412996）
