中国组织工程研究2017，Vol.38Issue(5)：789-794,6.DOI:10.3969/j.issn.2095-4344.2017.05.022
脂肪干细胞旁分泌功能在面部抗衰老领域的研究应用与进展
Research progress and application outlook of paracrine functions of adipose-derived stem cells in facial anti-aging
郭吉安 1余丕军 1王露萍 1石莹莹 1柳逸 1陈炜1
作者信息
- 1. 江苏大学附属上海市第八人民医院医学美容科，上海市 200235
- 折叠
摘要
Abstract
BACKGROUND:Adipose-derived stem cel s (ADSCs) are a subset of mesenchymal stem cel s obtained from adipose tissue, which have paracrine functions, already becoming a focus in anti-aging researching. OBJECTIVE:To review the research progress and application outlook of ADSCs’ paracrine functions in facial anti-aging. METHODS:The first author searched the PubMed and CNKI databases using the keywords of“adipose-derived stem cel s, paracrine, anti-aging”in English and Chinese, respectively, to retrieve relevant articles published from January 2001 to May 2016. Repetitive articles or those with no originality were eliminated. Total y 176 articles were searched initial y, and 66 articles were included in result analysis. RESULTS AND CONCLUSION:ADSCs have paracrine function, which can secrete various growth factors (e.g., epidermal growth factor, transforming growth factorβ, platelet-derived growth factor, vascular endothelial growth factor, col agen and fibronectin) and inflammatory factors (e.g., interferon-γ, interleukin-lβ, interleukin-8, interleukin-9, interleukin-12, interleukin-15, interleukin-17 and tumor necrosis factor-α). These paracrine products of ADSCs have significant effects on anti-aging, such as inhibiting skin aging, whitening skin, assisting lipotransfer, promoting hair regeneration.关键词
干细胞/脂肪干细胞/旁分泌/细胞因子/抗衰老/皮肤老化/美白/脂肪移植/脱发分类
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郭吉安,余丕军,王露萍,石莹莹,柳逸,陈炜..脂肪干细胞旁分泌功能在面部抗衰老领域的研究应用与进展[J].中国组织工程研究,2017,38(5):789-794,6.
