中国组织工程研究2017，Vol.38Issue(5)：802-808,7.DOI:10.3969/j.issn.2095-4344.2017.05.024
骨髓间充质干细胞移植治疗糖尿病神经源性膀胱的研究与进展
Bone marrow mesenchymal stem cells transplantation in the treatment of diabetic cystopathy
摘要
Abstract
BACKGROUND:Stem cel transplantation has gained considerable support recently. It provides new opportunities for treating diabetic neurogenic bladder. OBJECTIVE:To summarize the research progress in bone marrow mesenchymal stem cel s (BMSCs)transplantation in the treatment of diabetic neurogenic bladder. METHODS:The first author retrieved Sciencedirect, PubMed, Embase, Wangfang and CNKI databases, for relevant articles of BMSCs transplantation in the treatment of diabetic neurogenic bladder, published from 2000 to 2016. The key words were“bone marrow mesenchymal stem cel s, diabetic neurogenic bladder, differentiation, transplantation”in Chinese and English, respectively. RESULTS AND CONCLUSION:In patients with diabetic neurogenic bladder, the transplantation of BMSCs may provide safer and longer-lasting outcomes by repairing the damaged bladder and urethra. And it can produce various bioactive substances, which wil have nutritional paracrine effects on the bladder microenvironment, including anti-inflammation, promoting cel proliferation and improving cel survival. On the one hand, the BMSCs have the ability to migrate to the injury site via the blood circulation. On the other hand, BMSCs can produce various growth factors, as wel as the cytokines that can inhibit the inflammatory response. While the current clinical studies are lacking, its efficacy and safety needs further verification.关键词
干细胞/骨髓干细胞/糖尿病神经源性膀胱/修复重建/定向分化/移植/国家自然科学基金分类
医药卫生引用本文复制引用
杨亚飞,杨进,陈林,邢莎莎,胡海峰,张亚美,汪自力..骨髓间充质干细胞移植治疗糖尿病神经源性膀胱的研究与进展[J].中国组织工程研究,2017,38(5):802-808,7.基金项目
国家自然科学基金项目(81500577)；四川省卫计委资助项目(090112)；四川省教育厅资助项目(16ZA0383)Family Planning Commission of Sichuan Province, No.090112 （81500577）
the Funding Project of the Education Office of Sichuan Province, No.16ZA0383 （）
