诱导多能干细胞的安全性及应用研究进展
The safety and application of induced pluripotent stem cells
摘要
Abstract
BACKGROUND:Induced pluripotent stem cel technology have solved the contradiction between the ethics and immune rejection, and this high-efficient and safe technique is becoming the mainstream of today’s research. OBJECTIVE:To comprehensively review the safety and application of induced pluripotent stem cel s.METHODS:A computer-based online retrieval of PubMed and CNKI was performed to search relevant papers published from January 2006 to April 2016, with the key words of“induced pluripotent stem cel , reprogramming, clinical application, safety, transcription factor, disease mode”in English and Chinese, respectively. RESULTS AND CONCLUSION:In recent years, research on induced pluripotent stem cel s has attracted much attention from the scientific community and the medical community, and this technique has successful y gained induced pluripotent stem cel s and overcome the problems of immunity and ethics. However, it is limited to the theoretical and laboratory research due to the inability to solve the safety, efficiency and re-differentiation mechanism of induced pluripotent stem cel s. Therefore, we are faced with enormous difficulties and chal enges, which involve al aspects of basic research, including how to safely and effectively induce the differentiation of induced pluripotent stem cel s into the desired cel type and how to establish a suitable disease model as wel as a high-throughput drug screening platform.关键词
干细胞/诱导/诱导多能干细胞/重编程/临床应用/遗传安全性/转录因子/疾病模型/国家自然科学基金分类
医药卫生引用本文复制引用
田胜男,王博,李琦,黄元华,马燕琳..诱导多能干细胞的安全性及应用研究进展[J].中国组织工程研究,2017,38(5):815-820,6.基金项目
国家国际科技合作专项(2014DFA30180)；国家科技部973项目(2012CB966502)；国家自然科学基金(81060175，30860103，81460034，81260032，81060016，31140021)；海南省国际科技合作专项(GJXM20100004，GJXM201106，KJHZ2014-11)；人力资源和社会保障部2011年度留学人员科技活动择优资助项目；教育部归国留学人员启动基金项目；海南医学院创新性实验项目(HYCX201304)Funding:the International Science&Technology Cooperation Program of China, No.2014DFA30180 （2014DFA30180）
the National 973 Program of China, No.2012CB966502 （）
the National Natural Science Foundation of China, No.81060175,30860103,81460034,81260032,81060016,31140021 （）
the International Science and Technology Cooperation Program of Hainan Province, No. GJXM20100004, GJXM201106, KJHZ2014-11 （）
the 2011 Scientific Research Foundation for Overseas Students granted by the Human Resources and Social Security Ministry of China （）
the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry of China （）
the Innovative Experiment Project of Hainan Medical University, No. HYCX201304 （）
