中国组织工程研究2017，Vol.21Issue(7)：1009-1014,6.DOI:10.3969/j.issn.2095-4344.2017.07.005
SuperPATH微创入路人工股骨头置换治疗老年股骨颈骨折:前瞻性、开放性、随机对照临床试验
Supercapsular percutaneously-assisted total hip approach for the elderly with femoral neck fractures:study protocol for a prospective, open-label, randomized, controlled clinical trial
摘要
Abstract
BACKGROUND:Artificial hip replacement by the posterolateral approach is generally introduced as a treatment for femoral neck fracture in the elderly, but it is limited by the need for a large incision, cutting off the extortor, and postoperative hip dislocation. The supercapsular percutaneously-assisted total hip (SuperPATH) approach was developed based on the original lateral approach. The SuperPATH approach for hip replacement is characterized by the reduced chance of damaging blood vessels and nerves, reducing intraoperative blood loss, retaining all the joint capsules and supinator, and significantly reducing the incidence of postoperative hip dislocation. OBJECTIVE:We hypothesized that the SuperPATH approach for hip replacement can achieve better efficacy in the elderly with femoral neck fractures and promote the recovery of postoperative hip function compared with the posterolateral approach. METHODS/DESIGN:This is a prospective, single-center, open-label, randomized control ed clinical trial that will be completed at the Pudong Hospital of Fudan University, Shanghai, China. Forty patients with femoral neck fractures were randomly divided into two groups to undergo femoral head replacement by the SuperPATH approach in the experimental group, and by the conventional posterior approach in the control group. The follow-up period is 1 week and 6 months. The main outcome measures are Harris hip scores at baseline, and at 1 week and 6 months postoperatively to assess functional recovery of the hip. Secondary outcome measures to evaluate the advantages of the SuperPATH approach include the length of surgical incision, intraoperative blood loss, operative time, 24-hour postoperative drainage, and hospital stay. Other outcome measures include the incidence of adverse reactions at 1 week and 6 months after surgery. The study protocol was approved by the Ethics Committee of the Pudong Hospital of Fudan University, China, and performed in accordance with the guidelines of the Declaration of Helsinki, formulated by the World Medical Association. Written informed consent was obtained from all participants. DISCUSSION:The aim of this trial is to test our hypothesis that the SuperPATH approach is safer and more reliable for hip functional recovery compared with the posterolateral approach for the artificial hip replacement in femoral neck fractures of the elderly.关键词
骨科植入物/人工关节/人工股骨头置换/股骨颈骨折/SuperPATH微创入路/后外侧入路/老年/髋关节Harris评分/手术切口长度/术中出血量/手术时间/引流量/住院时间分类
医药卫生引用本文复制引用
吴良浩,禹宝庆,陈帆成..SuperPATH微创入路人工股骨头置换治疗老年股骨颈骨折:前瞻性、开放性、随机对照临床试验[J].中国组织工程研究,2017,21(7):1009-1014,6.基金项目
上海市卫生局重点课题(20134039) （20134039）
浦东新区卫生系统重点学科群建设资助(PWZxq2014-03) the Major Project of Shanghai Municipal Health Department, China, No. 20134039 （PWZxq2014-03）
and a grant from the Major Discipline Construction in the Health System Pudong New District, Shanghai, China, No. PWZxq2014-03. （）
