中国组织工程研究2017，Vol.21Issue(9)：1470-1476,7.DOI:10.3969/j.issn.2095-4344.2017.09.028
脐血干细胞治疗脑卒中的作用与机制
Effect and mechanism of umbilical cord blood stem cells in the treatment of stroke
刘婕 1张国华2
作者信息
- 1. 内蒙古医科大学,内蒙古自治区呼和浩特市 010059
- 2. 内蒙古医科大学第一附属医院神经内科,内蒙古自治区呼和浩特市 010059
- 折叠
摘要
Abstract
BACKGROUND: Studies have confirmed that umbilical cord blood stem cells can improve the neurologicalfunction after stroke, but the mechanism of umbilical cord blood stem cells in the treatment of stroke is unclear.OBJECTIVE: To review the effect and mechanism of umbilical cord blood stem cells in the treatment of stroke.METHODS: The first author searched PubMed and CNKI databases for relevant articles published from January2005 to December 2015 using key words of "umbilical cord blood stem cells, stroke" in English and Chinese,respectively. RESULTS AND CONCLUSION: With the further research on the neural differentiation of umbilical cord blood stem cells,umbilical cord blood stem cells have become a hot research topic in the field of neural system disease therapy. Atpresent, some experimental studies on cell transplantation for stroke have achieved ideal curative effects. However, themechanism of umbilical cord blood stem cells in the treatment of stroke is not clear. Known therapeutic mechanismsinclude the recombination of blood vessels, nerve loops and other damage tissue structures, secretion of variousnutritional factors to reduce endogenous apoptosis, promotion of endogenous blood vessels and nerve regeneration, etc.But the following problems need to be further studied, including whether the transplanted cells can be fully filled toreplace necrotic nerve cells and promote recovery of nerve function; how these survived stem cells establish the neuralconnections; how these transplanted cells reduce the apoptosis and necrosis of the host cells to restore the cell function.关键词
干细胞/脐带脐血干细胞/脐血干细胞/脑卒中/机制/综述分类
医药卫生引用本文复制引用
刘婕,张国华..脐血干细胞治疗脑卒中的作用与机制[J].中国组织工程研究,2017,21(9):1470-1476,7.
