西南国防医药2017，Vol.27Issue(3)：217-220,4.DOI:10.3969/j.issn.1004-0188.2017.03.001
极端高湿环境加重糖尿病心肌病心肌纤维化
Extreme high-humidity environment aggravates myocardial fibrosis in patients with diabetic cardiomyopathy
摘要
Abstract
Objective To explore the effects of high-humidity environment (especially the extreme high humidity environment) on myocardial fibrosis in patients with diabetic cardiomyopathy (DCM).Methods A DCM mouse model was established, and DCM mice were placed in the artificial climate chamber where a high humidity environment was simulated. The serum creatine kinase myocardial band (CK-MB), lactate dehydrogenase (LDH), brain natriuretic peptide (BNP), TNF-αand IL-1βlevels in myocardium and myocardial pathology were detected. Results The high-humidity environment caused changes of cardiac hemodynamics in DCM mice, and this resulted in the decrease of left ventricular diastolic function. With the increase of relative humidity, the activity of CK-MB, LDH and BNP in serum in the DCM group increased, the expression of TNF-α and IL-1β levels in myocardium increased, and the CVF, PVCA/LA and ROS in myocardium increased significantly (P<0.05).Conclusion As a kind of stimulus, a high-humid environment will cause inflammatory stress of myocardial cells and ventricular remodeling in patient with DCM, deteriorate the cardiac function, and increase secondary damage of DCM to myocardium.关键词
高湿环境/糖尿病心肌病/心肌纤维化/小鼠Key words
high-humidity environment/diabetic cardiomyopathy/myocardial fibrosis/mouse分类
医药卫生引用本文复制引用
侯君,郑德志,范泉水,李聃丹,呼永河..极端高湿环境加重糖尿病心肌病心肌纤维化[J].西南国防医药,2017,27(3):217-220,4.基金项目
中国博士后科学基金(201455M2600) （201455M2600）
四川省医学科研青年创新课题(Q14006) （Q14006）
2014年度全军后勤科研项目(BWS14J023) （BWS14J023）
