新医学2017，Vol.48Issue(2)：74-77,4.DOI:10.3969/j.issn.0253-9802.2017.02.002
成纤维细胞分化为肌成纤维细胞的调控机制
Mechanism of regulating the differentiation of cardiac fibroblasts into myofibroblasts
摘要
Abstract
Cardiomyocyte hypertrophy and cardiac fibrosis are the critical pathological features and major causes of cardiac remodeling.Previous studies have proven that fibroblasts and myofibroblasts play a ma-jor role during the process of cardiac remodeling.Myofibroblasts are extensively available and constantly experi-ence two stages of transformation.However,multiple transduction pathways and relevant regulatory factors par-ticipate in the complex transformation process including TGF-βsignaling transduction,angiotensin Ⅱ signa-ling,endothelin 1 signaling,transient receptor potential channels and mechanical transcriptional coupling,etc.关键词
肌成纤维细胞/成纤维细胞/转化生长因子-β/Smads 蛋白/血管紧张素ⅡKey words
Myofibroblast/Fibroblast/Transforming growth factor-β/Smads protein/Angiotensin Ⅱ引用本文复制引用
门素珍,马丽娟,石亚男,刘巍..成纤维细胞分化为肌成纤维细胞的调控机制[J].新医学,2017,48(2):74-77,4.基金项目
国家自然科学基金面上项目（81270310）；哈尔滨市科技创新人才研究专项资金（杰出青年人才）（2016RAYBJ005）；黑龙江省教育厅海外学人重点项目 （）
