眼科新进展2017，Vol.37Issue(2)：133-136,4.DOI:10.13389/j.cnki.rao.2017.0035
应用光学相干断层扫描量化评估糖尿病黄斑水肿的临床研究
Evaluating diabetic macular edema quantificationally by optical coherence tomography
摘要
Abstract
Objective To observe the changes of four quantitative indexes of diabetic macular edema by using optical coherence tomography.Methods Eighty-nine patients (155 eyes) with diabetic retinopathy were included in this project and were divided into two groups according to the present of diabetic macular edema:Negative group (56 cases,100 eyes) and positive group(33 cases,55 eyes).In addition,23 cases (42 eyes) of normal volunteers constituted the normal control group.All the objects accepted an optical coherence tomography examination and the indexes including central retinal thickness (CRT),subfoveal choroidal thickness (SFCT) and integrity of external limiting membrane(ELM) as well as inner/outer segment (IS/OS) were measured and analyzed.Results The average CRT of positive group (219.048 ± 16.798) μm was significantly thicker than that of control group(217.775 ± 26.866) μm and negative group (280.418 ±74.187) μm (P ＜0.001).Mean SFCT among control group (312.893 ±140.559) μm,negative group (302.080 ± 125.287) μm and positive group (293.745 ±140.517) μm had no statistical significance (P =0.781).There were 3 eyes with disrupted ELM layer in the negative group and 8 eyes in the positive group.Difference between them was proved to be significant (P =0.019).Similarly,the integrity of IS/OS layer had significant difference between negative group (5 eyes disrupted) and positive group (19 eyes disrupted) (P ＜ 0.001).Conelusion CRT of patients with diabetic macular edema is always increased and the integrity of ELM or (and) IS/OS can be disrupted in many cases.Indexes including CRT and the integrity of ELM or (and) IS/OS can be used to evaluate the severity of diabetic macular edema quantificationally.关键词
糖尿病黄斑水肿/光学相干断层扫描/黄斑中心凹/视网膜厚度/脉络膜厚度Key words
diabetic macular edema/optical coherence tomography/macular fovea/retinal thickness/choroidal thickness分类
医药卫生引用本文复制引用
董秀清,冯松福,柯晓云..应用光学相干断层扫描量化评估糖尿病黄斑水肿的临床研究[J].眼科新进展,2017,37(2):133-136,4.基金项目
国家自然科学基金资助(编号:81500722/H1205)National Natural Science Foundation of China (No:81500722/H1205) （编号:81500722/H1205）
