眼科新进展2017，Vol.37Issue(2)：184-188,5.DOI:10.13389/j.cnki.rao.2017.0048
TGF-β在角膜损伤修复中的时间和空间分布
Temporal and spatial distribution of TGF-β in corneal wound healing
摘要
Abstract
Fibrosis is the major cause of corneal scarring.Transforming growth factor-beta (TGF-β) plays a key role in corneal homeostasis and repair.Corneal epithelial basement membrane is thought to be the important barrier of corneal epitheliumstroma interaction.In different stages of corneal wound healing,the isoforms of TGF-β have different temporal and spatial expression.The integrity of basement membrane is a critical factor of these procedures.The temporal and spatial distributions of TGF-β isoforms play the crucial roles in cell migration,proliferation,phenotype changes and deposition of extracellular matrix in corneal wound healing.It is the mechanism of corneal scarring and scar-free healing.This article reviews recent articles to elucidate the biological functions of TGF-β and the temporal and spatial distribution of its isoforms in corneal wound healing.关键词
角膜损伤修复/转化生长因子-β/时空分布Key words
corneal wound healing/transforming growth factor-β/temporal and spatial distribution分类
医药卫生引用本文复制引用
张露,李霞..TGF-β在角膜损伤修复中的时间和空间分布[J].眼科新进展,2017,37(2):184-188,5.基金项目
国家自然科学基金资助(编号:81060076、81360144)National Natural Science Foundation of China (No:81060076,81360144) （编号:81060076、81360144）
