中国医疗设备2017，Vol.32Issue(3)：1-5,25,6.DOI:10.3969/j.issn.1674-1633.2017.03.001
苏木素作为外源性波谱标志物进行肿瘤MRS分子成像的初步研究
Hematoxylin as an Exogenous MR Spectroscopic Biomarker in Tumor Molecular Imaging: A Pilot Study
摘要
Abstract
Objective To discuss the basic problems of hematoxylin as an exogenous MR spectroscopic biomarker in tumor molecular imaging. Methods Different concentrations of hematoxylin solutions were performed high-field MR spectroscopy with the methods of Point Resolved Spectroscopy (PRESS) and Stimulated Echo Acquisition Mode (STEAM) respectively. Then the MR spectroscopy signal features of different concentrations of hematoxylin which was performed with different scanning methods were analyzed. Results The results showed that the specific MR spectroscopy signal profile of hematoxylin could be detected with both methods of PRESS and STEAM. The peak position was stable, while the peak height and peak area were related with the concentration of hematoxylin solution, the higher the concentration was, the more salient the specific MR spectroscopy signal profile was. Conclusion It was found that the hematoxylin has specific MR spectroscopic signal, which might make it a potential exogenous MR spectroscopic biomarker in tumor molecular imaging.关键词
分子成像/核磁共振波谱成像/外源性波谱标志物/苏木素/点解析波谱成像/激励回波采集模式Key words
molecular imaging/MR spectroscopic imaging/exogenous MR spectroscopic biomarker/hematoxylin/point resolved spectroscopy/stimulated echo acquisition mode分类
医药卫生引用本文复制引用
霍天龙,杨硕,陈雷,康钰,陈尘..苏木素作为外源性波谱标志物进行肿瘤MRS分子成像的初步研究[J].中国医疗设备,2017,32(3):1-5,25,6.基金项目
北京大学人民医院研究与发展基金(RDB2011-32) （RDB2011-32）
国家自然科学基金面上项目(81372363). （81372363）
