中国医疗设备2017，Vol.32Issue(3)：14-17,46,5.DOI:10.3969/j.issn.1674-1633.2017.03.004
一种用于碱金属流体热疗性能评价的仿组织透明体模
Transparent Tissue-Mimicking Phantom for Evaluating Effect of Alkali Metal Hyperthermia
摘要
Abstract
The method of alkali metal hyperthermia is rather unique in tumor ablation. Its basic principle is to produce a strong exothermic chemical reaction through the injection of trace alkali metals such as sodium, potassium or its alloy fluid by using the natural water environment in the target tissues, so as to achieve the goal of efficient directional thermal ablation. For the reason that the alkali metal ablation combines the advantages of thermal ablation and chemical ablation together, therefore, how to evaluate its ablation effect is a subject worth to be studied. So far, it is difficult to evaluate such double effects of ablation with non-standard biological tissues, for example, the use of liver tissue in vitro is very rare among the chemical ablation effect. Therefore, it is very important to establish a standardized and transparent phantom. This article mainly studied a kind of tissue transparent phantom for evaluating the properties of alkali metal hyperthermia. Such phantom was mainly mixed by polyacrylamide gel composition, egg white as a temperature sensitive indicator and phenolphthalein as the chemical sensitive indicator. The preliminary experimental results showed that this model can be used to evaluate the hyperthermia and chemotherapy effects of alkali metal ablation, and laid a foundation for further studying the heat release amount, diffusion properties of reaction product, the process of the fluid transport in biological tissues, as well as the ablation dose factors that affect the alkali metal treatment process.关键词
仿组织体模/碱金属热疗/聚丙烯酰胺/热化学消融/热疗效果评估/透明体模/钠钾合金Key words
tissue-mimicking phantom/alkali metal ablation/polyacrylamide/thermal-chemical ablation/hyperthermia effect evaluation/transparent phantom/sodium potassium alloy分类
医药卫生引用本文复制引用
杨鹏飞,王倩,陈柏炜,盛磊,刘静..一种用于碱金属流体热疗性能评价的仿组织透明体模[J].中国医疗设备,2017,32(3):14-17,46,5.基金项目
国家自然科学基金(NSFC 5137610) （NSFC 5137610）
创新品种临床前研究(Z141100000514005) （Z141100000514005）
中国博士后科学基金项目(2014M550747). （2014M550747）
