医药导报2017，Vol.36Issue(2)：171-174,4.DOI:10.3870/j.issn.1004-0781.2017.02.013
愈口宁对心脾积热型复发性口疮患者免疫功能的影响
Effects of Yukouning on Immunologic Function in Recurrent Aphthous Ulcer Patients with Brimming Heat of Heart and Spleen
摘要
Abstract
Objective To observe the effects of Yukouning on immunologic function in recurrent aphthous ulcer (RAU) patients with brimming heat of heart and spleen (BHHS type).Methods The study was composed of 30 patients with RAU (BHHS type) and 30 healthy individuals.All patients with RAU (BHHS type) were divided into levomisole group and Yukouning group (n =15).Patients of levomisole group were give 50 mg of levomisole,bid,lasted two days.Patients of Yukouning group were give Yukouning decoction.The changes of the class of T-cells and the levels of immunoglobulins (IgA,IgG,IgM) and complement (C3,C4) in different groups were tested by flow cytometry (FCM) and single immunodiffusion method.Results The levels of CD8+,IgG,IgA,C3 and C4 in RAU (BHHS type) patients increased significantly as compared with those in healthy group (P ＜ 0.05).The level of CD4+ and the ratio of CD4+/CD8+ decreased significantly as compared with those in healthy group (P ＜0.05).Furthermore,the levels of CD8+,IgG,IgA,C3 and C4 in RAU (BHHS type) patients decreased significantly after different drug treatment,respectively (P ＜ 0.05).At the same time,the level of CD8+ and the ratio of CD4+ / CD8+ increased significantly after different drug treatment,respectively (P ＜ 0.05).But all the above-mentioned indexes had no significant differences between the two drug groups (P ＞ 0.05).After 1-year follow-up,the effective rate (both 93.3％) had no significant difference between the two groups (P ＞ 0.05).Conclusion Imbalance of immune function is correlated with RAU (BHHS type).Yukouning plays a therapeutic role by regulating cellular and humoral immunity in RAU (BHHS type) patients.关键词
愈口宁/心脾积热/口疮,复发性/免疫功能Key words
Yukouning/Brimming heat of heart and spleen/Ulcer, recurrent aphthous/Immunologic function分类
医药卫生引用本文复制引用
王汉明,黄敏,周芳,朱晓密,雷敬,易娟..愈口宁对心脾积热型复发性口疮患者免疫功能的影响[J].医药导报,2017,36(2):171-174,4.基金项目
湖北省教育厅重点项目(D20121605) （D20121605）
