应用化学2017，Vol.34Issue(3)：316-323,8.DOI:10.11944/j.issn.1000-0518.2017.03.160219
含杂环1,4-戊二烯-3-酮肟酯类化合物的合成及生物活性
Synthesis and Biological Activity of Novel 1,4-Pentadien-3-one Oxime Esters Bearing Heterocycle Moiety
摘要
Abstract
In order to explore novel green pesticide with potent biological activities,a series of novel 1,4-pentadien-3-one oxime ester derivatives bearing heterocycle moiety,derived from curcumin,was designed and synthesized.Their structures were confirmed by infrared spectroscopy,proton nuclear magnetic resonance spectroscopy(1H NMR),13C NMR,and high resolution mass spectroscopy(HRMS).The bioassays indicate that inhibition rates of compound 5d against G.zeae,F.ox-ysporum and C.mandshurica at 50 mg/L are 64.75％,52.05％ and 69.68％,respectively,and compounds 5d,5e and 5f have good curative and deactivation activities against tobacco mosaic virus at 500 mg/L,with the inhibition rates of 56.93％ and 86.89％,53.08％ and 83.51％,and 53.40％ and 89.01％,respectively.These indicate that 1,4-pentadien-3-one oxime ester is a valuable scafford to develope new compounds poessessing high biological activities such as potential antifungal and antiviral activities.关键词
戊二烯-酮/肟酯/抑菌/抗病毒Key words
pentadien-one/oxime ester/fungicidal activities/antiviral activities分类
化学化工引用本文复制引用
夏丽娟,王晓斌,谢艳,王晓燕,肖维,钟新敏,黄民国,薛伟..含杂环1,4-戊二烯-3-酮肟酯类化合物的合成及生物活性[J].应用化学,2017,34(3):316-323,8.基金项目
国家自然科学基金(21462012) （21462012）
贵州省优秀青年科技人才培养对象专项资金(黔科合人字(2015)35号) （黔科合人字(2015）
贵州大学研究生创新基金(2016076)资助项目 （2016076）
Supported by the National Natural Science Foundation of China (No.21462012),the Special Fund for Outstanding Scientific and Technological Candidates of Guizhou Province(No.201535),the Innovation Fund for Graduate Student of Guizhou University(No.2016076) （No.21462012）
