诊断学理论与实践2017，Vol.16Issue(1)：88-92,5.DOI:10.16150/j.1671-2870.2017.01.017
多发性硬化症与EB病毒及白细胞介素17/白细胞介素23关联性分析
A study on correlation between multiple sclerosis and Epstein-Barr virus and IL-17/IL-23
摘要
Abstract
Objective:To study the expression of Epstein-Barr virus (EBV) autoantibodies and IL-17, IL-23 in cere-brospinal fluid of patients with multiple sclerosis (MS) and to define the relationship between IL-17/IL-23 and pathogenesis of MS for hoping to provide a diagnostic reference for clinical practice. Methods: Seventy-two patients with neurological diseases in Ruijin Hospital were categorized into 2 groups: 29 cases with central nervous system autoimmune disease (study group) and 43 cases of non-central nervous system autoimmune disease (control group). Enzyme-linked immunosor-bent assay (ELISA) was used to assess the levels of EBV-VCA-IgM, EBV-EBNA-1IgG, IL-17, IL-23 in CSF. Results:The expressions of EBV-EBNA-1IgG, EBV-VCA IgM and IL-23 in study group were significantly higher than those in control group (P<0.01). In study group, the expression of IL-23 in MS patients was significantly higher than that in control group (P<0.01), and the expression of IL-17 in MS patients was higher than that in control group (P<0.05). Conclusions: EBV is related to MS and probably contributes to the pathogenesis of MS. Meanwhile, the abnormal inflammatory axis of IL-17/IL-23 may also be related to the induction of MS. The study indicates a relationship of MS not only with viral infection, but also with a disordered autoimmune system.关键词
脑脊液/多发性硬化/EB病毒抗体/白细胞介素/酶联免疫吸附试验Key words
Cerebrospinal fluid/Multiple Sclerosis/EBV autoantibodies/Interleukin/Enzyme-linked immunosorbent assay分类
医药卫生引用本文复制引用
孟俊,彭奕冰,王学锋,陈呢喃,张冬青..多发性硬化症与EB病毒及白细胞介素17/白细胞介素23关联性分析[J].诊断学理论与实践,2017,16(1):88-92,5.基金项目
国家自然科学基金面上项目(31270963) （31270963）
上海市科委重点连续资助项目(10JC1408500) （10JC1408500）
上海交通大学医学院附属瑞金医院优青医技后备人才基金 （）
