诊断学理论与实践2017，Vol.16Issue(1)：98-103,6.DOI:10.16150/j.1671-2870.2017.01.019
急性缺血性卒中早期血浆miRNAs水平与房颤发生间的关系
Correlation of plasma miRNAs levels with atrial fibrillation in patients with acute cerebral infarction in early stage
摘要
Abstract
Objective:To investigate the correlation between the plasma miRNAs levels and atrial fibrillation (AF) in patients with acute cerebral infarction in early stage. Methods: Seven hundred and one patients with acute cerebral in-fraction addmitted in Gongli Hospital during Jan. 2014 to Nov. 2016 were enrolled, and patients were divided into two groups:group with AF(70 cases) and group without AF (631 cases), and 65 healthy cases were served as controls. Clinical data and miRNAs levels between the 3 groups were analyzed, and miRNAs levels were also compared between paroxysmal and persistent AF. Multivariate regression analysis was used to determine the contribution of plasma miRNAs variables to the presence of atrial fibrillation in patients with cerebral infarction in early stage. Results: Plasma levels of miR-328, miR-29b and miR-150 differed significantly between group with AF, group without AF and control group ( P<0.05, P<0.01). Different from miR-328 and miR-150, plasma level of miR-29b in cerebral infarction patients with paroxysmal AF was sig-nificantly lower than those in group without AF and controls (P<0.01). Logistic regression analysis showed that the specific miRNAs, miR-328, miR-29b and miR-150 were significantly associated with AF and miR-29b was significantly related to paroxysmal AF in patients with acute cerebral infarction. Conclusions: Levels of some specific plasma miRNAs, especially the miR-29b level might be used as predictor for the existing of AF in patients with acute cerebral infraction in early stage.关键词
急性缺血性卒中/心房颤动/微小RNAKey words
Acute cerebral infarction/Atrial fibrillation/MicroRNAs分类
医药卫生引用本文复制引用
胡荣郭,庞德芳,黄澍,沈振坤,陈玮,杨育伟,来小音,朱玮,吴菲菲..急性缺血性卒中早期血浆miRNAs水平与房颤发生间的关系[J].诊断学理论与实践,2017,16(1):98-103,6.基金项目
国家自然科学基金面上项目(81571203) （81571203）
上海市自然科学基金项目(15ZR1437200) （15ZR1437200）
上海市浦东新区科技发展基金(PKJ2014-Y21) （PKJ2014-Y21）
上海市浦东新区卫生系统领先人才培养计划(PWR12014-05) （PWR12014-05）
上海市浦东新区卫生系统重点学科建设资助(PWZx2014-08) （PWZx2014-08）
上海市医学重点专科建设计划项目(ZK2015B16) （ZK2015B16）
