中风与神经疾病杂志2017，Vol.34Issue(2)：108-111,4.
缺血性卒中患者血清抗磷脂蛋白抗体浓度与颈动脉粥样硬化的相关性
The relationship between serum level of anticardiolipin antibody and carotid atheroscleros IS in patients with acute cerebral infarction
摘要
Abstract
Objective To investigate the relationship between serum levels of anticardiolipin antibody ( ACA) and carotid atherosclerosis ( CAS) and its risk factors in patients with acute cerebral infarction ( IS) .Methods A total of 310 IS patients of internal carotid artery system were recruited and carotid arteries were measured by vascular doppler ultrasound instrument.According to the presence of carotid atherosclerotic plaque and the degree of carotid stenosis ,the patients were divided into three groups:group A (no plaque and stenosis) with 80 cases,group B (plaque but having no stenosis) with 101 cases,group C (plaque and stenosis) with 129 cases.Among the 129 patients of group C,case number of 1,2,3 and 4 grade of carotid stenos IS was 42,36,33 and 18 respectively.The serum levels of ACA were measured by ELISA and the routine biochemical indicators were detected at the same time .Results The serum level of ACA in patients of groups A ,B, C was (8.21 ±7.86) PLU/ml,(13.57 ±8.04) PLU/ml,(26.54 ±10.35) PLU/ml respectively.Serum level of ACA be-tween patients of group B and C was significantly higher than group A (P<0.05) and serum level of ACA was the highest in patients of group C .As carotid atherosclerosis stenosis progressed ,serum level of ACA antibody increased .Serum level of ACA antibody was positively associated with Triglyceride ( TG) .Conclusion Serum levels of ACA antibody play a role in the occurrence and development of carotid stenosis and TG was the independent risk factor of increased serum levels of ACA.Serum ACA may be used as one of the serum biochemical indexes of carotid artery atherosclerosis .关键词
抗心磷脂蛋白抗体/颈动脉粥样硬化/缺血性卒中Key words
Serum anticardiolipin antibody/Carotid atherosclerosis/Ischemic stroke分类
医药卫生引用本文复制引用
魏守超,刘君玲,赵兴军,孟颖,刘志辉..缺血性卒中患者血清抗磷脂蛋白抗体浓度与颈动脉粥样硬化的相关性[J].中风与神经疾病杂志,2017,34(2):108-111,4.基金项目
山东省自然科学基金(联合专项,No.ZR2015HL042) （联合专项,No.ZR2015HL042）
潍坊市科技技术发展计划项目(No.2015WS050) （No.2015WS050）
潍坊市卫生局科技项目(No.2014039) （No.2014039）
