中国当代儿科杂志2017，Vol.19Issue(3)：292-295,4.DOI:10.7499/j.issn.1008-8830.2017.03.008
过敏性紫癜患儿25-羟基维生素D3水平变化及意义
Changes in 25-hydroxyvitamin D3 level in children with Henoch-Sch(o)nlein purpura
张远达 1董青伟 1李荣敏 1冀超玉 1楚永涛 1马蕾 1张瑜1
作者信息
- 1. 保定市儿童医院儿内科,河北保定071000
- 折叠
摘要
Abstract
Objective To examine the changes in 25-hydroxyvitamin D3 [25-(OH)D3] level in children with Henoch-Sch(o)nlein purpura (HSP) and its clinical significance.Methods A total of 92 HSP children were included in this study,and were divided into HSP nephritis (HSPN) group (31 cases) and HSP group (61 cases) based on the presence or absence of HSPN.Alternatively,the patients were divided into purpura alone group (22 cases),purpura with joint symptoms group (joint symptom group,24 cases),purpura with gastrointestinal symptoms group (gastrointestinal symptom group,20 cases),and purpura with joint and gastrointestinal symptoms (mixed group,26 cases) based on their clinical symptoms.In addition,42 healthy children were selected as healthy control group.The level of 25-(OH)D3 in each group was measured using enzyme-linked immunoassay.Results The 25-(OH)D3 level in the HSP and HSPN groups was significantly lower than that in the healthy control group (P＜0.05),and the 25-(OH)D3 level in the HSPN group was significantly lower than that in the HSP group (P＜0.05).Although there was no significant difference in the 25-(OH) D3 level between the joint symptom,gastrointestinal symptom,and mixed groups (P=0.22),the 25-(OH) D3 level in the three groups was all significantly lower than that in the purpura alone group (P＜0.05).Conclusions The level of 25-(OH)D3 is reduced in children with HSP,particularly those with HSPN or with joint and gastrointestinal symptoms.Therefore,the reduction in 25-(OH)D3 level may serve as a predictor of whether HSP is associated with other impairments.关键词
过敏性紫癜/紫癜性肾炎/25-羟基维生素D3/儿童Key words
Henoch-Sch(o)nlein purpura/Purpura nephritis/25-Hydroxyvitamin D3/Child引用本文复制引用
张远达,董青伟,李荣敏,冀超玉,楚永涛,马蕾,张瑜..过敏性紫癜患儿25-羟基维生素D3水平变化及意义[J].中国当代儿科杂志,2017,19(3):292-295,4.
