中国防痨杂志2017，Vol.39Issue(2)：184-190,7.DOI:10.3969/j.issn.1000-6621.2017.02.016
深圳市耐多药结核病治疗效果及影响因素分析
Analysis of the efficacy and its influencing factors on multidrug-resistant tuberculosis in Shenzhen city
摘要
Abstract
Objective To analyze the efficacy and its influencing factors on multidrug-resistant tuberculosis (MDR-TB) in Shenzhen for the last seven years,and to provide scientific evidences for the formulation of MDR-TB clinical pathway and the optimization of treatment regimen in the future.Methods We conducted retrospective prospective cohort study in 165 registered cases with MDR-TB from Shenzhen during Oct.2006 to Oct.2013.Data including gender,age,marital status,primary treatment or retreatment,imaging and complications were collected.The influencing factors were analyzed in patients with successful treatment and poor outcome according to the classi fication of outcome.Single factor and multivariate logistic regression analysis was used the model of logistic regression.Results Of 165 cases with MDR-TB,there were successful treatment in 109 cases (66.1％),poor ourcomes in 21 cases (12.7％) and efficacy undetermined in 35 cases (21.2％).Single factor analysis showed that age (11.0％ (12/109) vs.33.3％ (7/21)),marital status (61.5％ (67/109) vs.85.7％ (18/21)) and complications (16.5％ (18/109) vs.42.9％ (9/21)) were closely related with outcome (Wald x2 =6.34,P=0.012;Wald x2 =4.10,P=0.043;Wald x2=6.81,P=0.009).Multivariate logistic regression analysis showed that age and complications were closely related with outcome.The risk of poor outcome in cases aged more than 40 years old was high than that in cases aged less than 40 years old (β=1.40,OR =4.03,95％ CI =1.30-12.53,Wald x2 =5.82,P =0.016).The risk of poor outcome in cases with complications was high than that in cases without complications (β=1.33,OR=3.79,95％CI=1.34-10.68,Wald x2=6.33,P=0.012).Conclusion Age and complication are the important influencing factors of treatment outcome for the patients with MDR-TB in Shenzhen city.Strengthen evaluation of efficacy,adjusting the treatment regimen whenever necessary and carrying on the individual treatment need to be strengthened in cases with aged more than 40 years old and with complications.关键词
结核,抗多种药物性/治疗结果/因素分析,统计学/回归分析Key words
Tuberculosis, multidrug-resistant/Treatment outcome/Factor analysis, statistical/Regression analysis引用本文复制引用
吕德良,谭卫国,张乐平,朱赛楠,李蓉安,罗育希,杨应周..深圳市耐多药结核病治疗效果及影响因素分析[J].中国防痨杂志,2017,39(2):184-190,7.基金项目
“十二五”国家科技重大专项(2012ZX10004903) （2012ZX10004903）
深圳市科技计划项目(201302154) （201302154）
