中国康复理论与实践2017，Vol.23Issue(3)：288-291,4.DOI:10.3969/j.issn.1006-9771.2017.03.008
运动或电针预处理对脑梗死大鼠神经功能缺损及层粘连蛋白表达的影响
Effects of Exercise or Electroacupuncture Preconditioning on Neurological Deficits and Expression of Laminin in Rats with Cerebral Infarction
摘要
Abstract
Objective To investigate the effect of electroacupuncture or exercise preconditioning on neurological function after focal ce-rebral infarction in rats and the possible mechanism. Methods A total of 24 male Sprague-Dawley rats were randomly divided into model group (n=6), sham group (n=6), exercise preconditioning group (n=6) and electroacupuncture preconditioning group (n=6). The model group and the sham group did not accept any treatment, while the exercise preconditioning group and the electroacupuncture precondition-ing group accepted treadmill training and electroacupuncture for two weeks, respectively. Their middle cerebral arteries were occluded with modified Longa's approach, except the sham group that was ligated the same arteries but did not result in infarction. They were evaluated with Neurologic Severity Scores (NSS) 24 hours after modeling, and the laminin expression in the ischemic area was detected with Western blotting. Results There was no neurological deficit in the sham group. The NSS was lower in both preconditioning groups than in the model group (P<0.05), but was not significant different between preconditioning groups (P>0.05). The expression of laminin was the most in the sham group, and was more in both preconditioning groups than in the model group (P<0.05), but was not significant different between pre-conditioning groups (P>0.05). Conclusion Preconditioning with exercise or electroacupuncture can both reduce the neurological deficits in rats after focal cerebral infarction, which may associate with the protection of laminin from inhibition in early stage.关键词
局灶性脑梗死/预处理/运动/电针/神经功能/层粘连蛋白/大鼠Key words
focal cerebral infarction/preconditioning/exercise/electroacupuncture/neurological function/laminin/rats分类
医药卫生引用本文复制引用
唐强,阮野,李宏玉,叶涛,吴孝军,田源,朱路文..运动或电针预处理对脑梗死大鼠神经功能缺损及层粘连蛋白表达的影响[J].中国康复理论与实践,2017,23(3):288-291,4.基金项目
1.国家自然科学基金项目(No.81503666) （No.81503666）
2.黑龙江中医药大学领军人才计划项目(No.2012RCL02) （No.2012RCL02）
3.黑龙江中医药大学研究生创新科研项目(No.yjscx2016037). （No.yjscx2016037）
