中国康复理论与实践2017，Vol.23Issue(3)：292-297,6.DOI:10.3969/j.issn.1006-9771.2017.03.009
人颞叶内侧癫痫海马组织星形胶质细胞Syntrophin的表达变化
Distribution of Astrocytic Syntrophin in Hippocampus from Human Mesial Temporal Lobe Epilepsy
摘要
Abstract
Objective To investigate the expression changes of astrocytic syntrophin in hippocampus from human mesial temporal lobe epilepsy (MTLE). Methods From April, 2015 to July, 2016, 17 cases of hippocampus, collected from temporal lobectomy, were divided into MTLE group (n=13) and non-MTLE group (n=4) according to hematoxylin and eosin staining, glial fibrillary acidic protein and neuronal nu-clei immunohistochemical staining. Immunofluorescence double labeling and immunofluorescence histochemistry were used to observe the expression of syntrophin. Results The proliferation of astrocytes increased and neurons reduced in the hippocampus of MTLE group. Syntro-phin was found in the membrane and foot processes of astrocyte, that was enriched along perivascular astrocyte end-feet domain in non-MTLE group, but lost in MTLE group. While the whole expression of syntrophin was more in MTLE group than in non-MTLE group (t=5.421, P<0.001). Conclusion The distribution of syntrophin in hippocampus astrocytes may be related to the development of MTLE.关键词
颞叶内侧癫痫/海马/星形胶质细胞/syntrophin/抗肌萎缩蛋白糖蛋白复合物Key words
mesial temporal lobe epilepsy/hippocampus/astrocyte/syntrophin/dystrophin-associated glycoprotein complex分类
医药卫生引用本文复制引用
王晓璇,孙振荣,吴敏,师忠芳,闫旭,徐立新,董丽萍,杨少华,袁芳..人颞叶内侧癫痫海马组织星形胶质细胞Syntrophin的表达变化[J].中国康复理论与实践,2017,23(3):292-297,6.基金项目
北京市自然科学基金项目(No. 7152027). （No. 7152027）
