中国临床药理学与治疗学2017，Vol.22Issue(2)：132-138,7.
黄芪总苷对糖尿病小鼠肾脏保护作用的研究
Protective effect of astragalosides on kidney damage in diabetic mice
摘要
Abstract
AIM:To study the effect of astragalosides(AST) on kidney damage and the mechanism in diabetic mice.METHODS:The diabetic mice model was established by intraperitoneal injection with STZ and the model mice were randomly divided into model group,tempol group,AST-L group,AST-M group,and AST-H group.After 4 weeks and 6 weeks of administration,concentration of fasting blood glucose (FBG) and glycosylated serum protein (GSP) were recorded;weight and kidney indexes were calculated;renal pathological changes were observed;glomerular apoptosis and renal TGF-beta 1,Col IⅣ mRNA expressions were detected by TUNEL and RT-PCR method,respectively.RESULTS:AST can significantly reduce the levels of serum FBG and GSP of diabetic mice induced by STZ in time and dose dependent way (P ＜ 0.01).After 6 weeks of administration,the body weight increased,while the kidney index,glomerulus defects and cell apoptosis decreased in all treatment group (P ＜ 0.01).Compared with model group,the high expression of Col Ⅳ mRNA and TGF-β1 mRNA were significantly decreased in kidney of AST 60 mg/kg dose group (P ＜ 0.05).CONCLUSION:There are some protective effects of AST on kidney of experimental diabetic mice,and its mechanism may be related to promote kidney Col Ⅳ,TGF-beta 1 mRNA expression.关键词
糖尿病/黄芪总苷/Ⅳ型胶原蛋白/转化生长因子-β1Key words
diabetes mellitus/astragalosides/Col Ⅳ/TGF-β1分类
医药卫生引用本文复制引用
刘晓云,张文,李卫平,公惠玲,韩佳,栾家杰..黄芪总苷对糖尿病小鼠肾脏保护作用的研究[J].中国临床药理学与治疗学,2017,22(2):132-138,7.基金项目
国家自然科学基金项目(81173624) （81173624）
安徽省自然科学基金项目(11040606M201) （11040606M201）
安徽省国际科技合作项目(12030603007) （12030603007）
