中国临床药理学与治疗学2017，Vol.22Issue(2)：139-143,5.
人参皂苷C-K对匹罗卡品致痫大鼠发作的影响
Effects of ginsenoside C-K on seizure activity in pilocarpine-induced epileptic rats
摘要
Abstract
AIM:To investigate the effects of ginsenoside C-K on behavior in epileptic rats and its synergistic effect with lamotrigine.METHODS:70 male SD rats were randomly divided into normal group,model group,lamotrigine group,ginsenoside C-K low,middle,high group,lamotrigine and ginsenoside C-K combination group.Rats in model group and treatment group were prepared for epilepsy animal model by intraperitoneal injection of lithium chloride-pilocarpine after administration of lamotrigine or ginsenoside C-K.Behavior changes were closely observed by video monitoring system after pilocarpine.Behavioural seizure activity was scored according to Racine grading standard and recorded seizure latency.RESULTS:After treatment of ginsenoside C-K,the treatment group rats exhibited significant an increase in seizure latency compared with epilepsy model group.The loss of body wieght reduced significantly in these surviving animals pretreated with ginsenoside C-K (n =10,P ＜ 0.05).Intriguingly,the complex of ginsenoside C-K and lamotrigine reduces seizure intensities,seizure latency was further prolonged(n =10,P ＜ 0.05).CONCLUSION:Ginsenoside C-K can exhibit an antiepileptic effect.The combination of ginsenoside C-K and lamotrigine have synergistic anti-epileptic effect.关键词
人参皂苷C-K/拉莫三嗪/癫痫/发作Key words
ginsenoside C-K/lamotrigine/epilepsy/seizure activity分类
医药卫生引用本文复制引用
曾祥昌,沈杰,欧阳冬生,周露萍,陈露露,罗伟,李超鹏,高青,王亚芹,王欣桐,胡凯..人参皂苷C-K对匹罗卡品致痫大鼠发作的影响[J].中国临床药理学与治疗学,2017,22(2):139-143,5.基金项目
国家自然科学基金(81301106,81503236,81641141) （81301106,81503236,81641141）
湖南省自然科学基金(14JJ4006) （14JJ4006）
湖南省自然科学基金(2016JJ4116) （2016JJ4116）
安徽高校自然科学研究重点项目(KJ2015A155) （KJ2015A155）
