中国临床药理学与治疗学2017，Vol.22Issue(2)：151-154,4.
姜黄素对Lewis肺癌小鼠血管内皮成长因子和endostatin表达的影响
Effects of curcumin on VEGF and endostatin expression of Lewis lung carcinoma
徐步远 1潘显阁 1陈崇别 1蔡敏 1徐露2
作者信息
- 1. 温州市平阳县人民医院,平阳325400,浙江
- 2. 重庆医科大学药学院,重庆400016
- 折叠
摘要
Abstract
AIM:To investigate the effects of curcumin on vascular endothelial growth factor (VEGF) and endostatin expression in lung tumor tissues isolated from Lewis lung carcinoma.METHODS:Three groups were established:the control,the tumor model and the curcumin treatment.Ten C57BL/6 mice were assigned into the control group.Another 20 mice were subcutaneously injected with Lewis cells into the right limb armpit and were randomly divided into the model group and the curcumin group,ten in each.20 mice of control and model groups were then administered intragastrically with 0.5％ CMC-Na solution for 14 days,while mice of the treatment group received suspension of curcumin (100 mg/kg) solution by gavage for 14 days.Lung tumor tissues were isolated from each group after final administration.Weights of the mice and Lung tumor tissues were measured.VEGF and endostatin expression were analyzed by Western blot and Q-PCR.RESULTS:Weigts of lung tumor tissues reduced significantly.VEGF expression increased in lung tumor tissues,while endostatin expression decreased.CONCLUSION:Curcumin inhibits the development of lung tumor through downregulating VEGF expression and up-regulating endostatin expression.关键词
姜黄素/血管内皮成长因子/endostatinKey words
curcumin/vascular endothelial growth factor/endostatin分类
医药卫生引用本文复制引用
徐步远,潘显阁,陈崇别,蔡敏,徐露..姜黄素对Lewis肺癌小鼠血管内皮成长因子和endostatin表达的影响[J].中国临床药理学与治疗学,2017,22(2):151-154,4.
