中国临床药理学与治疗学2017，Vol.22Issue(2)：160-164,5.
曲普利啶胶囊联合复方麻黄碱色甘酸钠膜治疗变应性鼻炎疗效及其对血清炎性因子影响
Effects of triprolidine tydrochloride capsules combined with compound ephedrine hydrochloride and cromolyn sodium pellicles on treating allergic rhinitis
摘要
Abstract
AIM:To study the effects of triprolidine hydrochloride capsules combined with compound ephedrine hydrochloride and cromolyn sodium pellicles on treating allergic rhinitis and its influence on the levels of inflammatory factors.METHODS:106 patients with allergic rhinitis were collected and were randomly divided into control group and observation group (53 cases each).The control group was given compound ephedrine hydrochloride and cromolyn sodium pellicles,while the observation group was administered with extra triprolidine hydrochloride capsules.The curative effect of allergic rhinitis,disappearance time of related symptoms (nasal itching,nasal congestion,sneezing,runny nose and headache),the levels of inflammatory factors (TNFα,IL-17,IL-4,IL-8 and IL-13) and the adverse actions were observed and compared.RESULTS:The total effective rate of observation group was 92.5％,which was significantly better than that of control group (79.2％).The nasal itching,nasal congestion,sneezing,runny nose and headache disappeared time in observation group were (1.61 ± 0.22) d,(1.83 ±0.26) d,(4.34±0.54) d,(2.37 ±0.24) d and (1.51 ±0.19) d,respectively,which were significantly shorter than those of the control group (P ＜ 0.05).Levels of TNF-α,IL-17,IL-4,IL-8 and IL-13 were (0.83 ±0.22) ng/mL,(43.15±5.21) ng/mL,(35.42 ± 10.65) ng/ mL,(113.12 ± 18.53) ng/mL and (5.44 ± 1.05) ng/mL,which were significantly lower than those of the control group (P ＜ 0.05).No significant difference was observed in adverse actions between the two groups.CONCLUSION:Triprolidine hydrochloride capsules combined with compound ephedrine hydrochloride and cromolyn sodium pellicles on treating allergic rhinitis can improve the therapeutic effect,which is worthy of further study.关键词
变应性鼻炎/曲普利啶胶囊/复方麻黄碱色甘酸钠膜/炎性因子Key words
allergic rhinitis/triprolidine hydrochloride capsules/compound ephedrine hydrochloride and cromolyn sodium pellicles/inflammatory factors分类
医药卫生引用本文复制引用
洪超群,吴亚庆,吕政纲,程可佳..曲普利啶胶囊联合复方麻黄碱色甘酸钠膜治疗变应性鼻炎疗效及其对血清炎性因子影响[J].中国临床药理学与治疗学,2017,22(2):160-164,5.基金项目
浙江省医药卫生一般研究计划(2013KYB112) （2013KYB112）
