中国临床药理学与治疗学2017，Vol.22Issue(2)：170-173,4.
米诺环素联合vitapex糊剂治疗持续性根尖周炎的临床研究
Clinical trial of minocycline hydrochloride combined with vitapex paste in the treatment of persistent apical periodontitis
摘要
Abstract
AIM:To observe the clinical efficacy and safety of minocycline hydrochloride combined with vitapex paste in the treatment of persistent apical periodontitis.METHODS:One hundred and two patients with persistent apical periodontitis were divided into control group (n =51) and treatment group (n =51) according to random number table method.The control group was treated with calcium hydroxide iodoform paste,and the treatment group was treated with vitapex paste a root canal combined with minocycline hydrochloride ointment.After 2 weeks and 3 months treatment,the clinical curative effect and adverse reaction were observed,the degree of pain was evaluated by visual analogue scale (VAS),and the levels of peripheral inflammatory factor were detected by ELISA.RESULTS:After two weeks,the total effective rate in treatment group was significantly higher than the control group (x2 =6.411,P =0.011).After 3 months,the total effective rate 94.12％ in treatment group was significantly higher than the control group 70.59％ (x2 =9.714,P =0.002).After treatment the VAS was lower than before treatment in two groups,the VAS of 3 months was significantly less than 2 weeks,and the VAS in treatment group was obvious lower than the control group,the difference was statistically significant (P ＜ 0.01).After treatment the levels of TNF-α,IL-2 and IL-8 were lower than before treatment in two groups,the levels of TNF-α,IL-2 and IL-8 of 3 months were significantly less than 2 weeks,and the treatment group was obvious lower than the control group,the difference was statistically significant (P ＜ 0.05).Two groups of patients were not seen obvious adverse reactions and discomfort symptoms.CONCLUSION:The minocycline hydrochloride combined with vitapex paste in the treatment of persistent apical periodontitis can reduce the patient's pain,decrease inflammation,increase clinical efficacy,and is relatively safe,which is worthy of popularization and application.关键词
持续性根尖周炎/米诺环素/vitapex糊剂/临床疗效/不良反应Key words
persistent apical periodontitis/minocycline hydrochloride/vitapex paste/clinical curative/adverse reactions分类
医药卫生引用本文复制引用
周淑珍,高云云,谢静,高孟飞..米诺环素联合vitapex糊剂治疗持续性根尖周炎的临床研究[J].中国临床药理学与治疗学,2017,22(2):170-173,4.基金项目
温州市科技局项目(Y20130260) （Y20130260）
