中国临床药理学与治疗学2017，Vol.22Issue(2)：179-183,5.
抗抑郁药物联合短期无抽搐电休克治疗对抑郁症疗效及认知功能的影响
Treatment of major depression with short-term MECT in addition to antidepressants: its effects on clinical efficacy and cognitive function
摘要
Abstract
AIM:To investigate effects of the acute and long-term clinical efficacy and cognitive function by using short-term modified electroconvulsive therapy (MECT) in addition to antidepressants for the treatment of major depression.METHODS:132 patients of major depression were divided into two groups:the control group (74 cases) and the experimental group (58 cases).Two groups were treated with antidepressants and antidepressants with short-term MECT.All patients were assessed on the first day of hospitalization,at the end of 1 st week,2nd week,34 week of hospitalization,after half year,and after one year based on Scale for the Hamilton depression scale (HAMD) and Wechsler Memory Scale (WMS).The adverse effects and the length of hospital stay in acute phase were assessed using treatment-emergent symptom scale (TESS).RESULTS:At the end of 2nd week and 3rd week of hospitalization,there was significant difference (P ＜ 0.05) in HAMD but no significant difference (P ＞ 0.05) in TESS scores between the experimental group and the control group.WMS score in the experimental group was worse than the control group at the end of 3rd week of hospitalization.However,there was significant difference (P ＜ 0.05) in WMS after half year and one year.The recurrence rate of the experimental group was lower than that of the control group at the end of 12 months.CONCLUSION:Using adequate antidepressants with shortterm MECT during outbreak of major depression helped to improve the long-dated negative symptoms and cognitive function.Adequate antidepressants combined with short-term MECT is an effective treatment program,which can help to improve the depressive symptoms promptly and thoroughly,and reduce the length of hospital stay in acute phase and long-term risk of recurrence rate,but also to avoid cognitive impairment of MECT due to too many times of MECT.关键词
重性抑郁症/抗抑郁药物/无抽搐电休克/汉密尔顿抑郁量表/韦氏记忆量表Key words
major depression/antidepressants/modified electroconvulsive therapy/Hamilton depression scale/Wechsler Memory Scale分类
医药卫生引用本文复制引用
钟智勇,陶炯,王相兰,韩洪瀛,李凌江..抗抑郁药物联合短期无抽搐电休克治疗对抑郁症疗效及认知功能的影响[J].中国临床药理学与治疗学,2017,22(2):179-183,5.基金项目
广东省科技计划项目(2010B080701040) （2010B080701040）
