中国临床药理学与治疗学2017，Vol.22Issue(2)：198-203,6.
CYP2E1调控酒精性肝病发病机制的研究进展
Research on the progress of alcoholic liver disease pathogenesis related to CYP2E1
摘要
Abstract
Alcoholic liver disease (ALD) is a kind of liver damage caused by long-term drink or heavy drink by a couple of weeks.Cytochrome P450 2El (CYP2E1),as a main enzyme metabolizing enzyme of alcohol,plays an important role in the toxic metabolism of alcohol and the occurrence and development of ALD.The expression of CYP2E1 in vivo,the activity of CYP2E1 and free oxygen radicals and toxic metabolites produced during the metabolism of alcohol by CYP2E1 can affect the process and development of ALD in different ways.The regulation mechanisms related to CYP2E1 is involved with multiples of pathogenic molecules,pathogenesis and signaling pathways.The interplay and reciprocal action between signaling pathways could have an influence on self-protection and the occurrence and development of ALD.This review mainly summarizes the research progresses of signaling pathways both in protective and injury mechanisms that regulate the progress of ALD through CYP2E1.Our effort could provide help for the prevention and treatment of ALD in future.关键词
酒精性肝病(ALD)/CYP2E1/Wnt-β-catenin/JNK-MAPK/NF-κB/TGF-β-SmadsKey words
alcoholic liver disease/CYP2E1/Wnt-beta-catenin/JNK-MAPK/NF-κB/TGF-β-Smads分类
医药卫生引用本文复制引用
陈丹,林秀贤,陈尧..CYP2E1调控酒精性肝病发病机制的研究进展[J].中国临床药理学与治疗学,2017,22(2):198-203,6.基金项目
国家自然科学基金项目(81302850) （81302850）
长沙市科技计划项目(kq1602014) （kq1602014）
中南大学中央高校基本科研业务费专项基金资助(2016zzts512) （2016zzts512）
