中国临床药理学与治疗学2017，Vol.22Issue(2)：204-209,6.
miRNA调控肿瘤相关基因c-met的研究进展
Advances in research of miRNA regulated tumor-associated gene c-met
摘要
Abstract
C-met is the member of the tyrosine kinase receptor (receptor tyrosinekinases,RTKs) family.It can change different signal pathways in cell after combination with its ligand hepatocyte growth factor (HGF).The microRNA (miRNA) is a kind of highly conservative,endogenous,non-coding single small RNA whose length is about 19-25 nucleotides.It regulates gene expression after transcription by affecting the stability of the target mRNA or inhibit its translation.It plays an important role in many biological processes in the biological process.Studies have shown that miRNAs can regulate the expression of c-met,inhibit tumor cell proliferation,migration and invasion.Regarding the miRNA related to tumor gene c-met regulation research progress are summarized.关键词
酪氨酸激酶受体/c-met/miRNA/肿瘤Key words
receptor tyrosinekinases/c-met/miRNA/tumor分类
医药卫生引用本文复制引用
梅颖,刘朝奇..miRNA调控肿瘤相关基因c-met的研究进展[J].中国临床药理学与治疗学,2017,22(2):204-209,6.基金项目
国家自然科学基金面上项目(81473461) （81473461）
