中国临床药理学与治疗学2017，Vol.22Issue(2)：233-240,8.
熊脱氧胆酸在慢性肝病中应用及机制的再认识
Recognition of the clinical application and biological mechanism of ursodeoxycholic acid in liver diseases
摘要
Abstract
Ursodeoxycholic acid (UDCA) has been widely used in clinical treatment of liver disease due to its hepato-protective effect,including primary biliary cirrhosis (PBC),primary sclerosing cholangitis (PSC) and cystic fibrosis (CF),etc.Lack of effective drug as control,UDCA's clinical effect and mechanism of action remain unclear.Recently,the reports about adverse events caused by UDCA,especially at high dosage have been increasing.This review summarizes the clinical application and mechanism of UDCA in treatment of liver diseases,which is referential for its clinical application.关键词
熊脱氧胆酸/肝病/利胆剂/毒性Key words
ursodeoxycholic acid/liver disease/cholagogue/toxicity分类
医药卫生引用本文复制引用
张林林,樊玉娟,谭波,李玥,蒋健,裘福荣..熊脱氧胆酸在慢性肝病中应用及机制的再认识[J].中国临床药理学与治疗学,2017,22(2):233-240,8.基金项目
国家自然科学基金资助项目(81173118) （81173118）
