中国临床医学2017，Vol.24Issue(1)：93-96,4.DOI:10.12025/j.issn.1008-6358.2017.20160811
复发性视神经脊髓炎患者外周血记忆T细胞与IL-7水平的变化
Changes of memory T cells and IL-7 level in peripheral blood of patients with relapsing neuromyelitis optica
王金涛 1李野 1董丽华 1隋世华 1李加梅 1郑加平 1周广喜2
作者信息
- 1. 山东省日照市人民医院神经内科,日照276800
- 2. 天津医科大学总医院神经内科,天津 300052
- 折叠
摘要
Abstract
Objective:To observe the changes of memory T cells (CD4+ CD45RA- T cell)and IL-7 level in peripheral blood of patients with relapsing or non-relapsing neuromyelitis optica,and discuss the role of memory T cells in NMO relapsing mechanism.Methods:The proportion of CD4+CD45RA-cells in the relapsing NMO group (n= 15),the non-relapsing NMO group (n= 17 )and the healthy control group (n= 15 )was detected by flow cytometry.Plasma interleukin 7 (IL-7)levels were measured by enzyme-linked immunosorbent assay (ELISA)in all 3 groups.The correlation of CD4+CD45RA- cell ratio with IL-7 level in 32 patients was analyzed.Results:The CD4+CD45RA-cell ratio in the relapsing group (32.86±5.53)%was higher than that in the non-relapsing group (19.98±5.72)%and the healthy control group (19.59± 4.49)%,and the differences were statistically significant (P<0.01);the ratio in the non-relapsing group was higher than that in the control group,but the difference was not statistically significant.The IL-7 level in the relapsing group ([418.73 ± 78.96]pg/mL)was higher than that in the non-relapsing group ([313.33±57.65]pg/mL)and the healthy control group ([303.43±40.48]pg/mL),and the differences were statistically significant (P<0.01);the IL-7 level in the non-relapsing group was higher than that in the healthy control group,but the difference was not statistically significant.The CD4+CD45RA- cell ratio was significantly correlated with IL-7 level in NMO patients (r= 0.817,P= 0.000 ).Conclusions:Memory T cells participate in the relapsing process of neuromyelitis optica (NMO),while IL-7 promotes the cytopoiesis and function of memory T cells.关键词
视神经脊髓炎/复发/记忆T细胞/IL-7Key words
neuromyelitis optica/relapse/memory T cells/IL-7分类
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王金涛,李野,董丽华,隋世华,李加梅,郑加平,周广喜..复发性视神经脊髓炎患者外周血记忆T细胞与IL-7水平的变化[J].中国临床医学,2017,24(1):93-96,4.
