中国临床医学影像杂志2017，Vol.28Issue(3)：153-156,4.
脑胶质瘤1H-MRS胆碱相对值与肿瘤增殖抗原Ki-67表达的关系
Correlation between Cho/Cr ratio and expression of Ki-67 in brain glioma
胡丽娟 1廖凯兵1
作者信息
- 1. 湖北省中西医结合医院放射科,湖北武汉430015
- 折叠
摘要
Abstract
Objective:To study the 3.0T multivoxel proton magnetic spectroscopy(1H-MRS) findings in brain glioma and to investigate the correlation between Cho/Cr ratio and expression of Ki-67.Methods:Fifty-seven patients of brain gliomas were studied,including 28 cases of low-grade group(grade Ⅰ ～Ⅱ),29 cases of high-grade group(grade Ⅲ～Ⅳ).All of them under went 3.0T 1H-MRS examination before operation.The Cho/Cr ratios were detected.We analyzed the correlation between Cho/ Cr ratio and pathological grade of gliomas.Ki-67 immunohistochemical staining and Ki-67 labeling index(Ki-67LI) were mea sured after operation.We also analyzed the correlation between Ki-67LI and the pathological grade,the Cho/Cr ratio of gliomas.Results:①Significant differences were found in the ratios of Cho/Cr between low grade gliomas and high grade gliomas (P＜0.001).The ratio of Cho/Cr was positively correlated with the tumor grade (r=0.616,P＜0.001).The area under the curve(AUC) of Cho/Cr was 0.856.The threshold value of Cho/Cr ratio for differential diagnosis high grade and low grade brain gliomas was 2.44,the sensitivity was 79.3％,the specificity was 82.1％.②Ki-67LI of low grade glioma was (3.41±2.35)％,Ki-67LI of high grade glioma was (19.78±11.45)％,the difference was statistically significant(Z=-0.617,P＜0.001).The Ki-67LI was positively correlated with the tumor grade and the Cho/Cr ratio (r=0.804,P＜0.001).Conclusion:The Cho/Cr ratios of gliomas are correlated with the expression of Ki-67.It may be a useful image index,which can evaluate the proliferation activity and malignancy degree of glioma,without invasion.And it may be helpful in the clinical treatment and prognosis assessment.关键词
神经胶质瘤/Ki-67抗原/磁共振成像Key words
Glioma/Ki-67 antigen/Magnetic resonance imaging分类
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胡丽娟,廖凯兵..脑胶质瘤1H-MRS胆碱相对值与肿瘤增殖抗原Ki-67表达的关系[J].中国临床医学影像杂志,2017,28(3):153-156,4.
