中国美容医学2017，Vol.26Issue(2)：76-80,5.
巴沙鱼胶原蛋白支架材料的成骨效果评估
Osteogenetic Effects of Collagen Scaffold Material from Basa Fish (Pangasisushaniltoa) Skin on GBR of Rabbit Skull Defect
摘要
Abstract
Objective To research the effects of collagen scaffold material from Basa fish skin on the repair of the rabbit skull defects. Methods Acycloid skull defect with the diameter of 8mm was made on both sides of the sagittal suture of 12 rabbits.The rabbits were randomly divided in to 3 groups.The skull defects were treated with implantation of Bio-Oss,collagen scaffold material from Basa fish skin+Bio-Oss, Bio-Gide+Bio-Oss, respectively. After 8 and 12 weeks,6 rabbits were sacrificed respectively and the bone samples were examined by HE staining. Results Collagen scaffold material from Basa fish skin could play a role as barrier membrane in guiding and promoting osteogenesis in rabbit skull defects. There was no significant difference between group B and group C in promoting osteogenesis at 8 week after treatment(P>0.05) but both more than group A(P<0.05).At 12 week, group B is better than group A(P<0.05)and worse than group C. Conclusion Collagen scaffold material from Basa fish skin can promote osteogenesis in bone defect.关键词
引导骨组织再生/鱼类胶原蛋白/兔颅骨缺损模型/胶原蛋白支架材料/牙种植术Key words
guided bone regeneration/fish collagen/rabbit skull defect models/collagen scaffold material from fish/Dental implants分类
生物科学引用本文复制引用
陈彤,吴刚,祖丽皮也,朱庆丰,王少海,易杨华..巴沙鱼胶原蛋白支架材料的成骨效果评估[J].中国美容医学,2017,26(2):76-80,5.基金项目
海洋公益性行业科研专项(201405015 （）
201305013)资助 （）
国家自然科学基金(81271177)资助 （81271177）
