中国全科医学2017，Vol.20Issue(4)：437-442,6.DOI:10.3969/j.issn.1007-9572.2017.04.012
内脏脂肪指数对成人生长激素缺乏症患者代谢综合征的评估作用研究
Value of Visceral Adiposity Index in Predicting Metabolic Syndrome in Adult Growth Hormone Deficiency
摘要
Abstract
Objective To investigate the value of visceral adiposity index (VAI) in predicting metabolic syndrome (MS) in adult growth hormone deficiency (AGHD).Methods From January 2015 to January 2016,we selected 66 patients diagnosed with AGHD 2 or over 2 years ago in the First Affiliated Hospital of Chongqing Medical University,and 66 controls underwent physical examination in Medical Examination Center in the hospital during the same period as the AGHD group and the control group,respectively.The AGHD group was further assigned to 3 groups,low-VAI subgroup,middle-VAI subgroup and upper-VAI subgroup with 22 patients in each based on the VAI tertile value.We measured all the subjects' height,weight,waist circumference (WC),hip circumference (HC),blood pressure [systolic blood pressure (SBP) and diastolic blood pressure (DBP)],fasting plasma glucose (FPG),fasting insulin (FINS),blood lipid [total cholesterol (TC),triacylglycerol (TG),low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C)].Body mass index (BMI),waist-hip ratio (WHR),honeostasis model assessment of insulin resistance (HOMA-IR) and VAI were calculated.The value of VAI in the prediciton of MS in AGHD was explored by analyzing the calculated area under curve (AUC) of receiver operating characteristic (ROC) cmve.Results Both the AGHD group and the control group had the same number of males (21) and females (45).The diffrences in terms of age,height,SBP,DBP,FPG and TC between the AGHD group and the control group were not statistically significant (P ＞ 0.05).Compared with those in control group,weight,BMI,WC,HC,WHR,FINS,TG,LDL-C,VAI,and HOMA-IR were increased in AGHD group,while HDL-C was lower in AGHD group (P ＜ 0.05).There were no prominently statistical differences in sex,age,height,WHR,FINS,TC and LDL-C between the low-VAI subgroup,middle-VAI subgroup and upper-VAI subgroup (P ＞ 0.05),while notable differences were observed in weight,BMI,WC,HC,SBP,DBP,FPG,TG,HDL-C,HOMA-IR and incidence of MS between the 3 subgroups (P ＜ 0.05).VAI was positively correlated with WC,DBP,FPG,and TG (P ＜ 0.05),but negatively associated with HDL-C (P ＜ 0.05),and it had no relation with SBP (P ＞ 0.05) no matter adjusting for age or not.Results of ROC curve analysis showed that VAI was a significant discriminator for MS in AGHD patients,the AUC of VAI was 0.871 [95％CI (0.788,0.954),P ＜0.001],the optimal critical value was 1.9,the sensitivity was 0.960,and the specificity was 0.610.Conclusion VAI is significantly correlated with MS in AGHD patients,which can be a reliable diagnostic method for MS in AGHD patients.关键词
成人生长激素缺乏症/内脏脂肪指数/代谢综合征XKey words
Adult growth hormone deficiency/Visceral adiposity index/Metabolic syndrome X分类
医药卫生引用本文复制引用
李庆,刘婵,夏佳佳,郑晓雅,谢欣,任伟..内脏脂肪指数对成人生长激素缺乏症患者代谢综合征的评估作用研究[J].中国全科医学,2017,20(4):437-442,6.基金项目
教育部基金项目(20135503120001) （20135503120001）
国家临床重点专科建设项目(2011) （2011）
重庆市科委自然科学基金面上项目(estc2012jjA10035) （estc2012jjA10035）
