摘要
Abstract
In the physiological process,the heart and kidney work together,complement and compensate for the function of the other organ,and they are the two most important organs in maintaining the stability of the circulatory system. At this point,the other organ is bound to be affected if the function of any of the two organs changes. The maintenance of this stability is very complex and involves the fine regulation between cardiac and renal functions and the control of neuroendocrine activity, including the natriuretic peptide family,rennin angiotensin aldosterone system and sympathetic nervous system. The dysfunction or diseases of an organ can cause,aggravate,or directly participate in the functional damage and disease progression of another organ and form a vicious circle (mutual damage). In addition,the interaction between the heart and kidney is also affected simultaneously by some diseases or risk factors,including aging,hypertension,diabetes,atherosclerosis,etc. (co -morbidity). Only taking arteriosclerosis as an example,the large arteriosclerosis itself caused by the changes of the aging mechanical stress can independently involved in the occurrence of dysfunction and disease of the two organs. However,in the progressive stage of nephropathy,the stability of hemodynamics and neuroendocrine is damaged,the capacity load and pressure load increases significantly,and the risk of heart and kidney injury increases. At the same time,some of the drug clearance and metabolism are also affected. All these factors contribute to the risk of the coexistence of heart and kidney diseases,especially in the elderly. When the two kinds of disease coexist,the effect of pathological damage will significantly enlarge,which indicates a poor prognosis,and medication should be cautious. Therefore,the concept of prevention of heart and kidney disease and integration of diagnosis and treatment needs to be extensively promoted and popularized.关键词
心肾综合征/心力衰竭/急性肾损伤/述评Key words
Cardio - renal syndrome/Heart failure/Acute kidney injury/Editorial分类
医药卫生
