中国全科医学2017，Vol.20Issue(9)：1037-1041,5.DOI:10.3969/j.issn.1007-9572.2017.09.004
腔隙性脑梗死后非痴呆性血管性认知功能障碍的临床特点及影响因素研究
Clinical Characteristics and Influencing Factors of Vascular Cognitive Impairment Not Dementia after Lacunar Infarction
摘要
Abstract
Objective To explore the clinical characteristics and influencing factors of vascular cognitive impairment not dementia (VCIND)after lacunar infarction (LI). Methods According to the diagnostic criteria of LI,135 patients from Department of Neurology,the First Affiliated Hospital of Xinjiang Medical University from December 2015 to June 2016 were recruited to be scored in reference to related cognitive neural scale. 76 patients with VCIND and 44 patients in normal cognitive state were screened out into VCIND group and control group (NC group)respectively. Age,gender,years of education,history of hypertension,history of diabetes mellitus,history of hyperhomocysteinemia,history of transient ischemic attack,smoking history,drinking history,grading of intracranial and carotid artery stenosis,score of white matter lesion and score of cognitive function of patients in the two groups were compared,and the relationship between the above factors and VCIND after LI was analyzed. Results There were significant differences in age,years of education,history of hypertension,the score of mini -mental state examination (MMSE)and Montreal cognitive assessment (MoCA)of patients between the two groups (P < 0. 05). The grading of intracranial and carotid artery stenosis and the score of DWMHs in NC group were better than those in VCIND group(P < 0. 05). The vascular stenosis degree of 3rd and 4th grade,and DWMHs of 3 scores were the risk factors of VCIND after LI, and years of education was the protective factor of VCIND after LI (P > 0. 05). Conclusion The cognitive impairment of patients with VCIND after LI is manifested in visual space,executive function,naming,attention,abstraction,and ability of delayed recall,and vascular stenosis degree of 3rd and 4th grade in head and neck,and deep white matter lesion are associated with cognitive impairment of patients with VCIND after LI.关键词
腔隙性脑梗死/认知功能障碍/痴呆,血管性/神经心理学测验Key words
Infarction/lacunar/Cognition disorders/Dementia/vascular/Neuropsychological test分类
医药卫生引用本文复制引用
何丹,杜磊,马建华,张小宁,郝晨光..腔隙性脑梗死后非痴呆性血管性认知功能障碍的临床特点及影响因素研究[J].中国全科医学,2017,20(9):1037-1041,5.基金项目
新疆维吾尔自治区自然科学基金资助项目(2015211C085) （2015211C085）
