中国全科医学2017，Vol.20Issue(9)：1098-1103,6.DOI:10.3969/j.issn.1007-9572.2017.09.015
基于功能性磁共振成像在正常与病理状态下针刺外关穴时脑负激活的脑区定位研究
Identification of Deactivated Brain Regions by Real and Non - penetrating Sham Acupuncture Stimulation on Waiguan: An fMRI Study in Normal Versus Pathological Conditions
摘要
Abstract
Objective To study the law of identification of deactivated brain regions by real and non - penetrating sham acupuncture stimulation on Waiguan (Point te5)in normal versus pathological conditions based on fMRI. Methods The subjects enrolled in this study were 24 normal controls selected from Southern Medical University between August and December 2013,and 20 ischemic stroke patients from Nanfang Hospital and the First Affiliated Hospital of Guangzhou University of Chinese Medicine between January and June 2014. We conducted real and non - penetrating sham acupuncture stimulation on the right Point te5 in all the subjects,respectively and collected the signal data of brain deactivations with blood oxygenation level -dependent (BOLD)fMRI and processed the data using SPM2 (P≤0. 001,uncorrected,number of biotin K > 30). Results In the normal controls,the brain regions deactivated by real acupuncture stimulation on Point te5 were as follows:left superior parietal lobule (BA7),left inferior parietal lobule (BA40),left precuneus (BA7,19),left superior frontal gyrus (BA6), left precentral gyrus (BA6,10 ),left postcentral gyrus (BA3,7 ),left occipital lobe (BA19 ),right precentral gyrus (BA6),right postcentral gyrus (BA3),right precuneus (BA19,7),right cuneus (BA19);the brain regions deactivated by non - penetrating sham acupuncture stimulation on Point te5 were left precentral gyrus (BA10),left postcentral gyrus (BA3, 5),and right superior frontal gyrus (BA10). In the ischemic stroke patients,the brain regions deactivated by real acupuncture stimulation on Point te5 were as follows:left medial frontal gyrus (BA6,10),left postcentral gyrus (BA3),left middle temporal gyrus (BA21 ),right postcentral gyrus (BA3,5 ),right precentral gyrus (BA4 ),right medial frontal gyrus (BA10);the brain regions deactivated by non - penetrating sham acupuncture stimulation on Point te5 were left and right precuneuses (BA7). Conclusion Real acupuncture stimulation on Point te5 can deactivate the functional brain regions in both the normal controls and ischemic stroke patients,which suggests that the stimulation of Point te5 may be associated with the deactivation of brain regions;the deactivated functional brain regions in the normal controls are different from those in the ischemic stroke patients when the same kind of acupuncture stimulation given to them is disturbed or interrupted.关键词
针刺/穴,外关/磁共振成像/脑负激活Key words
Acupuncture/Point te5 (waiguan)/Magnetic resonance imaging/Brain deactivation分类
医药卫生引用本文复制引用
张贵锋,黄泳,唐纯志,赖新生,陈俊琦..基于功能性磁共振成像在正常与病理状态下针刺外关穴时脑负激活的脑区定位研究[J].中国全科医学,2017,20(9):1098-1103,6.基金项目
国家重点基础研究发展计划(973项目)(2006CB504505,2012CB518504) （973项目）
国家自然科学基金重大研究计划(90709027) （90709027）
广东省中医药强省课题(20141306) （20141306）
肇庆市科技创新计划(2015040304-10) （2015040304-10）
