The authors acknowledge financial support from the following organizations: Medical Research Council, Wellcome Trust Stem Cell Institute (Cambridge), NIHR Cambridge Biomedical Research Center, the Biotechnology and Biological Sciences Research Council and the Engineering and Physical Sciences Research Council. The authors have no other relevant afliations or financial involvement with any organi-zation or entity with a financial interest in or financial conflict with the subject matter or materials discussed in this manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents, received or pending, or royalties. No writing assistance was utilized in the production of this manuscript. （Cambridge）