中国实验动物学报2017，Vol.25Issue(1)：102-106,5.DOI:10.3969/j.issn.1005-4847.2017.01.019
动物模型在间充质干细胞治疗慢性肝病临床前研究的应用
A review on the application of animal models in preclinical research of the treatment of liver diseases with mesenchymal stem cells
摘要
Abstract
Chronic liver diseases can further develop to liver fibrosis and cirrhosis. Currently, there is no effective treatment except liver orthotopic transplantation at this point. The extreme shortage of liver organ source forced people to find alternative treatment strategies. Mesenchymal stem cells ( MSCs) have the abilities of immunomodulatory, hepatocyte differentiation, promotion of liver cells regeneration in situ and inhibiting the activation of hepatic stellate cells. Therefore, MSCs transplantation provides a very broad prospect for cell therapy. It is important to provide preclinical evaluation of the efficacy and safety before the application of cell therapy in clinical trials. The progress of various animal models of human liver diseasees and significance of using MSCs to treat liver diseases in preclincal studies based on these animal models were reviewed in this paper.关键词
肝病动物模型/间充质干细胞/临床前研究Key words
Liver disease/animal models/Mesenchymal stem cells/MSCs/Preclincal study分类
生物科学引用本文复制引用
付旭锋,陈冰冰,严亚萍,王宏,王峻峰,郑冰蓉,司维..动物模型在间充质干细胞治疗慢性肝病临床前研究的应用[J].中国实验动物学报,2017,25(1):102-106,5.基金项目
国家重点研发计划项目(2016YFA0101400) （2016YFA0101400）
国家重大科学研究计划重大科学问题目标导向项目(2012CBA01305) （2012CBA01305）
云南省中青年学术和技术带头人后备人才及云南省技术创新人才(2012HB040). （2012HB040）
