中国比较医学杂志2017，Vol.27Issue(1)：54-58,5.DOI:10.3969.j.issn.1671-7856.2017.01.011
氧化槐果碱对小鼠炎症性疼痛的镇痛作用研究
Oxysophocarpine ameliorates carrageenan-induced inflammatory pain via inhibiting expressions of prostaglandin E2 and cytokines in mice
摘要
Abstract
Objective In this study we investigated the analgesic effect of oxysophocarpine ( OSC ) on carrageenan-induced inflammatory pain in mice and to explore its possible mechanism .Methods Mouse ear swelling test and carrageenan-induced paw edema were used to investigate the effects of OSC (10, 40 and 80 mg/kg) on inflammatory pain in mice .The mechanical hyperalgesia and allodynia were measured by von Frey filaments .Paw edema was assessed by toe volumetric measuring instrument .text the content of TNF-α, IL-1β, IL-6 and PGE2 .Results OSC showed a significant anti-inflammatory effect in the mouse ear swelling test .OSC (10, 40 and 80 mg/kg) also significantly reduced the paw edema volume and improved mechanical allodynia threshold value on carrageenan -induced inflammatory pain , as well as relieved paw tissues inflammatory damage and reduced the numbers of neutrophils in mice .OSC significantly suppressed over-expression of TNF-α, IL-1β, IL-6 and PGE2 .Conclusions Based on these findings we propose that OSC attenuates inflammatory pain by suppressing the Pro-inflammatory cytokines .关键词
氧化槐果碱/炎性疼痛/炎性细胞因子Key words
Oxysophocarpine/Inflammatory pain/Pro-inflammatory cytokines分类
医药卫生引用本文复制引用
吴璟,杨文,郑婕,杨洋,黎伟华,赵玉萍,李凤梅,马鹏生,余建强..氧化槐果碱对小鼠炎症性疼痛的镇痛作用研究[J].中国比较医学杂志,2017,27(1):54-58,5.基金项目
宁夏高等学校科学研究项目( NGY2014097 ). （ NGY2014097 ）
