中国比较医学杂志2017，Vol.27Issue(1)：73-78,6.DOI:10.3969.j.issn.1671-7856.2017.01.015
淫羊藿苷对实验性IgA肾病大鼠的作用及相关机制
Effects of Icariin of experimental IgA nephropathy in rats
张红 1刘念 2李征3
作者信息
- 1. 郑州大学附属南阳市中心医院肾病风湿免疫科,河南南阳 473400
- 2. 郑州大学附属南阳市中心医院骨二科,河南南阳 473400
- 3. 郑州大学附属南阳市中心医院泌尿外科,河南南阳 473400
- 折叠
摘要
Abstract
Objective To investigate the effect of Icariin ( ICA) experimental IgA nephropathy in rats and to explore related mechanisms .Methods Experimental IgA nephropathy rat model was established and then model rat were treated with or without different doses of ICA .Then, urine RBC, Urine protein and urine NAG were analyzed; IgA precipitation was detected with immunofluorescence staining;the protein level of NF-κBp65 and MCP-1 were examined by immunohistochemical staining;the mRNA level of IL-4, IL-10 and IL-13 were determined by quantitative PCR .Results The concentrations of urine RBC, Urine protein and urine NAG were reduced after ICA treatment , as companied by a decrease of IgA precipitation .Moreover, ICA treatment also decreased the protein level of NF-κBp65 and MCP-1, and the mRNA level of IL-4, IL-10 and IL-13.Conclusions ICA exerts a certain degree of efficacy on the treatment of experimental IgA nephropathy through regulating NF-κBp65 and MCP-1 expression and the immunoregulation mechanism .关键词
淫羊藿苷/IgA肾病/NF-κBp65/MCP-1/IL-4/IL-10/IL-13Key words
Icariin/IgA nephropathy/NF-κBp65/MCP-1/IL-4/IL-10/IL-13引用本文复制引用
张红,刘念,李征..淫羊藿苷对实验性IgA肾病大鼠的作用及相关机制[J].中国比较医学杂志,2017,27(1):73-78,6.
