中国比较医学杂志2017，Vol.27Issue(1)：91-98,8.DOI:10.3969.j.issn.1671-7856.2017.01.018
人源肿瘤异种移植模型在精准肿瘤医学中的研究进展
Research progress of patient-derived xenografts in precision cancer medicine
摘要
Abstract
Cancer is a group of heterogeneous disease caused by diverse genomic alterations in oncogenes and tumor suppressor genes .Despite recent advances in high-throughput sequencing technologies and development of targeted therapies, novel cancer drug development is limited due to the high attrition rate from clinical studies .Patient-derived xenografts ( PDX) models are generated by implanting sectioned patient tumor fragments into immunodeficient mice .PDX models retain many of the key characteristics of patients ' tumors including histology , genomic signature , cellular heterogeneity , and drug responsiveness .These models cannot only serve as a platform for co-clinical trials by enabling the integration of clinical data , genomic profiles , and drug responsiveness data to determine precisely targeted therapies , but also be applied to the development of biomarkers for drug responsiveness and personalized drug selection .This review summarizes our current knowledge of this field , including methodologic aspects , applications in drug development , challenges and limitations , and utilization for precision cancer medicine .关键词
人源性肿瘤异种移植/PDX模型/个性化治疗/精准医学Key words
Patient-derived xenografts/PDX models/Individual treatment/Precision medicine分类
医药卫生引用本文复制引用
李克娟,黄昊,高苒..人源肿瘤异种移植模型在精准肿瘤医学中的研究进展[J].中国比较医学杂志,2017,27(1):91-98,8.基金项目
北京市优秀人才培养资助项目(2015000020124G073). （2015000020124G073）
