中国实用外科杂志2017，Vol.37Issue(3)：281-283,3.DOI:10.19538/j.cjps.issn1005-2208.2017.03.17
合并肝细胞癌多原发癌临床特点 (附25例报告)
Clinical characteristics of multiple primary malignancies in patients with hepatocellular carcinoma:A report of 25 cases
摘要
Abstract
Objective To explore the clinical characteristics of multiple primary malignances(MPM)in patients with hepatocellular carcinoma(HCC). Methods The clinical data of 25 cases of MPM with HCC admitted between January 2012 and June 2016 in the Second Affiliated Hospital of Zhejiang University School of Medicine were analyzed retrospectively. Results Twenty-five cases of MPM accountted for 5.5%of HCC cases (458 cases) admitted in the same period. Among the 25 cases of MPM,8(32%)cases were synchronous carcinoma and the other 17(68%)cases were metachronous carcinoma ,of which 12 initial malignances occurred in extrahepatic organs and 5 initial malignances presented HCC. A total of 26 extrahepatic malignant tumors were found in 25 cases. Lung cancer(26.9%)is the most common lesion in extrahepatic organ,followed by gastric cancer (23.1%). As to the therapeutic method of HCC, 1 (4.0%) case received transcatheter arterial chemoembolization (TACE),2 (8.0%) cases received palliative therapy, and the other 22 (88.0%) cases suffered radical operation. The 1- and 3-year survival rate were 86.4% and 72.7%, respectively. Conclusion MPM associated with HCC is not rare. Lung and stomach are common organs invaded by extrahepatic tumors. It's necessary to have a better knowledge of MPM to reduce the misdiagnosis rate to make a reasonable therapeutic decision.关键词
肝癌/多原发癌Key words
hepatocellular carcinoma/multiple primary malignancies分类
医药卫生引用本文复制引用
孙培伟,白雪莉,陈义刚,高顺良,张匀,楼健颖,阙日升,梁廷波..合并肝细胞癌多原发癌临床特点 (附25例报告)[J].中国实用外科杂志,2017,37(3):281-283,3.基金项目
国家自然科学基金面上项目(No.81472212) （No.81472212）
浙江省医药卫生科技省部共建项目(No.WKJ-ZJ-1410) （No.WKJ-ZJ-1410）
浙江省中医药科技计划重点项目(No.2014ZZ007) （No.2014ZZ007）
