中国现代医学杂志2017，Vol.27Issue(4)：33-39,7.DOI:10.3969/j.issn.1005-8982.2017.04.007
组蛋白修饰的结肠癌临床预后价值与年龄的相关性研究
Age-dependent clinical prognostic value of histone modifications in colorectal cancer
贾业贵 1王国樑2
作者信息
- 1. 江汉大学附属医院 消化内科,湖北 武汉 430015
- 2. 江汉大学医学院,湖北 武汉 430056
- 折叠
摘要
Abstract
Objective To assess the expression of histone modifications in tumor cells of the patients with TNM stage Ⅰ-Ⅲ colorectal cancer (CRC) and its clinical outcome and association with age at surgery. Methods To quantify expression, immunohistochemical staining of the histone modifications was performed on a tissue microarray containing colorectal tissues of the 254 patients with TNM stage Ⅰ-Ⅲ CRC. The patients were stratified according to survival status and age-related tumor expression patterns of both H3K9ac and H3K27me3 were compared. Results Decreased expression with advancing age was observed in the patients who were alive after follow-up (no-event group), whereas increased expression with advancing age was observed in the patients who presented with a recurrence or death during follow-up (event group). These opposite expression patterns translated into age-dependent prognostic value of the individual histone modifications and their combination in CRC. The prognostic value reversed with increasing age, high nuclear expression associated with good clinical outcome in the young adults, in contrast, with poor clinical outcome in the elderly patients. Conclusions We identified an age-dependent prognostic effect of nuclear expressions of histone modifications H3K9ac and H3K27me3 and their combination in patients with CRC. We have demonstrated for the first time the prognostic impact of an epigenetic marker can not only change but also reverse with increasing age. This observation supports the hypothesis that CRC biology is distinct between young adults and the elderly and emphasizes the importance of focusing on age-related effects in CRC.关键词
结肠癌/预后价值/组蛋白修饰/年龄Key words
colorectal cancer/prognostic value/istone modifications/age分类
医药卫生引用本文复制引用
贾业贵,王国樑..组蛋白修饰的结肠癌临床预后价值与年龄的相关性研究[J].中国现代医学杂志,2017,27(4):33-39,7.
