中国现代医学杂志2017，Vol.27Issue(4)：126-130,5.DOI:10.3969/j.issn.1005-8982.2017.04.026
帕利哌酮治疗精神分裂症的血药浓度与临床疗效研究
Correlation between Paliperidone plasma concentration and clinical efficacy in treatment of schizophrenia
孙文文 1程宇琪 1陈娴瑜 1许秀峰 1白燕1
作者信息
- 1. 昆明医科大学第一附属医院 精神科,云南 昆明 650032
- 折叠
摘要
Abstract
Objective To examine the correlations of Paliperidone plasma concentration with drug dose, clinical efficacy and side effects in patients with schizophrenia. Methods The patients with schizophrenia were treated by Paliperidone. The plasma concentration was monitored by high-performance liquid chromatography-tandem mass spectrometry (RP-HPLC) at the end of the 1st, 2nd and 4th week. The clinical efficacy was evaluated using the Positive and Negative Syndrome Scale (PANSS) and the side effects were evaluated by the Treatment Emergent Symptom Scale (TESS) at the baseline and at the end of the 1st, 2nd and 4th week after treatment. The blood routine, urinalysis, liver and kidney functions, electrocardiogram and prolactin level detection were done at baseline and the 4th weekend after treatment. Results The Paliperidone dosages [(7.24 ±1.50), (8.89 ± 1.29), (9.63 ± 1.77)] were positively correlated with the blood concentrations [(18.64 ± 7.93), (25.44 ± 10.71), (27.65 ±13.89)] at the end of the 1st, 2nd and 4th week after treatment (P <0.05). The plasma concentration of Paliperidone was correlated with serum prolactin level in the female patients ( P< 0.05). The plasma concentration of Paliperidone was not correlated with the reduction rate of PANSS scores, TESS or the value of weight gain (P > 0.05). There was no significant difference in the plasma concentration of Paliperidone between the effective and ineffective groups or between the extrapyramidal reaction group and the non-extrapyramidal reaction group ( P> 0.05). Conclusions There is a positively nonlinear correlation between the plasma concentration and the dose of Paliperidone. There is a positive correlation between the Paliperidone plasma concentration and serum prolactin level.关键词
精神分裂症/治疗药物监测/帕利哌酮/血药浓度/临床疗效Key words
schizophrenia/therapeutic drug monitoring (TDM)/Paliperidone/plasma concentration/clinical efficacy分类
医药卫生引用本文复制引用
孙文文,程宇琪,陈娴瑜,许秀峰,白燕..帕利哌酮治疗精神分裂症的血药浓度与临床疗效研究[J].中国现代医学杂志,2017,27(4):126-130,5.
